Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

Y Wang, R Branicky, A Noë, S Hekimi - Journal of Cell Biology, 2018 - rupress.org
Superoxide dismutases (SODs) are universal enzymes of organisms that live in the
presence of oxygen. They catalyze the conversion of superoxide into oxygen and hydrogen …

Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications

J Zielonka, J Joseph, A Sikora, M Hardy… - Chemical …, 2017 - ACS Publications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

[HTML][HTML] ROS scavenging Mn 3 O 4 nanozymes for in vivo anti-inflammation

J Yao, Y Cheng, M Zhou, S Zhao, S Lin, X Wang… - Chemical …, 2018 - pubs.rsc.org
Reactive oxygen species (ROS)-induced oxidative stress is linked to various diseases,
including cardiovascular disease and cancer. Though highly efficient natural ROS …

[PDF][PDF] Classification of metal-based drugs according to their mechanisms of action

E Boros, PJ Dyson, G Gasser - Chem, 2020 - cell.com
Metal-based drugs and imaging agents are extensively used in the clinic for the treatment
and diagnosis of cancers and a wide range of other diseases. The current clinical arsenal of …

[HTML][HTML] Oxidative stress, inflammation and colorectal cancer: An overview

A Bardelčíková, J Šoltys, J Mojžiš - Antioxidants, 2023 - mdpi.com
Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths
worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors …

[HTML][HTML] Superoxide dismutase administration: A review of proposed human uses

AC Rosa, D Corsi, N Cavi, N Bruni, F Dosio - Molecules, 2021 - mdpi.com
Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …

[HTML][HTML] Functions and dysfunctions of nitric oxide in brain

P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …

[HTML][HTML] Superoxide dismutases and superoxide reductases

Y Sheng, IA Abreu, DE Cabelli, MJ Maroney… - Chemical …, 2014 - ACS Publications
Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Mediation of oxidative stress toxicity induced by pyrethroid pesticides in fish

C Yang, W Lim, G Song - Comparative Biochemistry and Physiology Part C …, 2020 - Elsevier
Organophosphate and organochlorine pesticides are banned in most countries because
they cause high toxicity and bioaccumulation in non-target organisms. Pyrethroid pesticides …

Self‐assembly of multi‐nanozymes to mimic an intracellular antioxidant defense system

Y Huang, Z Liu, C Liu, E Ju, Y Zhang… - Angewandte …, 2016 - Wiley Online Library
In this work, for the first time, we constructed a novel multi‐nanozymes cooperative platform
to mimic intracellular antioxidant enzyme‐based defense system. V2O5 nanowire served as …