The variant gambit: COVID-19's next move
More than a year after its emergence, COVID-19, the disease caused by SARS-CoV-2,
continues to plague the world and dominate our daily lives. Even with the development of …
continues to plague the world and dominate our daily lives. Even with the development of …
Phosphoregulation of phase separation by the SARS-CoV-2 N protein suggests a biophysical basis for its dual functions
The nucleocapsid (N) protein of coronaviruses serves two major functions: compaction of the
RNA genome in the virion and regulation of viral gene transcription. It is not clear how the N …
RNA genome in the virion and regulation of viral gene transcription. It is not clear how the N …
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication
TM Yaron, BE Heaton, TM Levy, JL Johnson… - Science …, 2022 - science.org
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal
human diseases. Although vaccine development targeting these viruses has been …
human diseases. Although vaccine development targeting these viruses has been …
Melatonin: Regulation of viral phase separation and Epitranscriptomics in post-acute sequelae of COVID-19
The relentless, protracted evolution of the SARS-CoV-2 virus imposes tremendous pressure
on herd immunity and demands versatile adaptations by the human host genome to counter …
on herd immunity and demands versatile adaptations by the human host genome to counter …
[HTML][HTML] The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins
KV Tugaeva, DEDP Hawkins, JLR Smith… - Journal of Molecular …, 2021 - Elsevier
The coronavirus nucleocapsid protein (N) controls viral genome packaging and contains
numerous phosphorylation sites located within unstructured regions. Binding of …
numerous phosphorylation sites located within unstructured regions. Binding of …
Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication
Viral proteins are known to be methylated by host protein arginine methyltransferases
(PRMTs) necessary for the viral life cycle, but it remains unknown whether severe acute …
(PRMTs) necessary for the viral life cycle, but it remains unknown whether severe acute …
[HTML][HTML] Assembly of SARS-CoV-2 ribonucleosomes by truncated N∗ variant of the nucleocapsid protein
The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) compacts the RNA genome into viral ribonucleoprotein (vRNP) complexes within …
CoV-2) compacts the RNA genome into viral ribonucleoprotein (vRNP) complexes within …
Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation
The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 is
responsible for compaction of the∼ 30-kb RNA genome in the∼ 90-nm virion. Previous …
responsible for compaction of the∼ 30-kb RNA genome in the∼ 90-nm virion. Previous …
On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine
ABSTRACT RNA processing plays a key role in gene expression, allowing for increased
protein diversity and functional complexity. Consequently, modulating RNA processing can …
protein diversity and functional complexity. Consequently, modulating RNA processing can …
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro
TM Yaron, BE Heaton, TM Levy, JL Johnson… - BioRxiv, 2020 - biorxiv.org
While vaccines are vital for preventing COVID-19 infections, it is critical to develop new
therapies to treat patients who become infected. Pharmacological targeting of a host factor …
therapies to treat patients who become infected. Pharmacological targeting of a host factor …