The etiology of Ménière's disease (MD) remains controversial. Allergies are potential
extrinsic factors that, in conjunction with underlying intrinsic factors, may cause MD. The link …

With the very recent market approval of pitolisant (Wakix®), the interest in clinical
applications of novel multifunctional histamine H3 receptor antagonists has clearly …

Background Autoimmunity may play an important role in sudden onset sensorineural
hearing loss. However, little is known about the relationship between immunoglobulin E …

The saccule is one of the vestibular sensory organs of the inner ear. It detects head
movements and provides information to maintain balance and orient in space. Despite its …

The pathology of Meniere's disease (MD) is well established to be endolymphatic hydrops.
However, the mechanism underlying deafness and vertigo of MD or idiopathic …

Although the evidence of a causal association between allergy and Menière's disease is
inconclusive, the inclusion of allergy control as part of the treatment plan for Menière's …

The human endolymphatic sac (ES) is situated in a duplicature of the dura in the posterior
cranial fossa and constitutes a part of the inner ear. The sac possesses immunological …

Abstract Purpose of Review The purpose of this review was to describe the ongoing
research that supports that Meniere's disease (MD) is a heterogeneous set of clinical …

Objective: Betahistine is a histamine-like drug that is used in the treatment of Ménière's
disease. It is commonly believed that betahistine increases cochlear blood flow and thus …

Conclusion The present findings show that all four types of histamine receptors (H1R, H2R,
H3R, and H4R) are present in the inner ear, thus supporting the hypothesis that histamine …