The nature of embryonic stem cells
G Martello, A Smith - Annual review of cell and developmental …, 2014 - annualreviews.org
Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …
Mapping the route from naive pluripotency to lineage specification
T Kalkan, A Smith - … Transactions of the Royal Society B …, 2014 - royalsocietypublishing.org
In the mouse blastocyst, epiblast cells are newly formed shortly before implantation. They
possess a unique developmental plasticity, termed naive pluripotency. For development to …
possess a unique developmental plasticity, termed naive pluripotency. For development to …
[HTML][HTML] Reorganization of enhancer patterns in transition from naive to primed pluripotency
Naive and primed pluripotency is characterized by distinct signaling requirements,
transcriptomes, and developmental properties, but both cellular states share key …
transcriptomes, and developmental properties, but both cellular states share key …
Cancer stem cells: from historical roots to a new perspective
JP Capp - Journal of oncology, 2019 - Wiley Online Library
The relationships between cancer and stemness have a long history that is traced here.
From the mid‐19th century when the first theory on the embryonic origin of cancer was …
From the mid‐19th century when the first theory on the embryonic origin of cancer was …
[HTML][HTML] Role of Oct4 in the early embryo development
G Wu, HR Schöler - Cell Regeneration, 2014 - Springer
Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction
with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem …
with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem …
A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential
HY Zhou, Y Katsman, NK Dhaliwal… - Genes & …, 2014 - genesdev.cshlp.org
The Sox2 transcription factor must be robustly transcribed in embryonic stem (ES) cells to
maintain pluripotency. Two gene-proximal enhancers, Sox2 regulatory region 1 (SRR1) and …
maintain pluripotency. Two gene-proximal enhancers, Sox2 regulatory region 1 (SRR1) and …
Sox2/Oct4: A delicately balanced partnership in pluripotent stem cells and embryogenesis
A Rizzino, EL Wuebben - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Considerable progress has been made in understanding the roles of Sox2 and Oct4 in
embryonic stem cells and mammalian embryogenesis. Specifically, significant progress has …
embryonic stem cells and mammalian embryogenesis. Specifically, significant progress has …
[HTML][HTML] Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation
Stem cells undergo cellular division during their differentiation to produce daughter cells
with a new cellular identity. However, the epigenetic events and molecular mechanisms …
with a new cellular identity. However, the epigenetic events and molecular mechanisms …
[HTML][HTML] MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner
RL Dos Santos, L Tosti, A Radzisheuskaya… - Cell stem cell, 2014 - cell.com
Summary The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for
embryonic development and pluripotent stem cell differentiation. In this study, we …
embryonic development and pluripotent stem cell differentiation. In this study, we …
[HTML][HTML] Mesenchymal stem/stromal cells derived from human and animal perinatal tissues—origins, characteristics, signaling pathways, and clinical trials
Mesenchymal stem/stromal cells (MSCs) are currently one of the most extensively
researched fields due to their promising opportunity for use in regenerative medicine. There …
researched fields due to their promising opportunity for use in regenerative medicine. There …