Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …

Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute
myocardial infarction (MI) and to mediate long-standing fibrosis with chronic disease …

Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and
under physiological conditions. In the adult heart, activated cardiac fibroblasts also …

Cardiac fibrosis is a pathological condition that occurs after injury and during aging.
Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying …

The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …

Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular
matrix deposition and consequent mechanical stiffness, myocyte uncoupling, and ischemia …

In a cell-free approach to regenerative therapeutics, transient application of paracrine factors
in vivo could be used to alter the behavior and fate of progenitor cells to achieve sustained …

Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …

Cardiac fibrosis remains an important health concern, but the study of fibroblast biology has
been hindered by a lack of effective means for identifying and tracking fibroblasts. Recent …