Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Sickle cell disease results in numerous complications that can lead to significant morbidity
and mortality. Amongst them, acute chest syndrome is the leading cause of mortality. As a …

Hemolytic diseases are frequently linked to multiorgan failure subsequent to vascular
damage. Deciphering the mechanisms leading to organ injury upon hemolytic event could …

Hepatobiliary complications in children with sickle cell disease (SCD) are rarely reported but
can be life-threatening. We retrospectively assessed their prevalence in a cohort of 616 …

Sickle hepatopathy is an umbrella term describing various pattern of liver injury seen in
patients with sickle cell disease. The disease is not uncommon in India; in terms of …

The root cause of sickle cell disease (SCD) has been known for nearly a century, however,
few therapies to treat the disease are available. Over several decades of work, with …

The nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3)
inflammasome is a critical inflammatory mechanism identified in platelets, which controls …

Objectives Bilirubin, a by-product of heme degradation, is suggested to have a role for
vascular protection. There is increasing evidence that bilirubin may directly affect the …

Sickle cell disorder (SCD) refers to a spectrum of hematologic disorders that cause a
characteristic clinical syndrome affecting the entire body. It is the most prevalent …

Sickle cell disease (SCD) is an autosomal recessive genetic disorder that affects∼ 100,000
Americans and millions of people worldwide. Erythrocyte sickling, vaso-occlusion, sterile …