The incidence of colorectal cancer (CRC) is increasing worldwide. CRC has high mortality
when detected at advanced stages, yet it is also highly preventable. Given the difficulties in …

Colorectal cancer is a heterogeneous disease that develops via stepwise accumulation of
well-characterized genetic and epigenetic alterations. We review the genetic changes …

1 ESGE recommends cold snare polypectomy (CSP) as the preferred technique for removal
of diminutive polyps (size≤ 5 mm). This technique has high rates of complete resection …

Serrated polyps have been recognised in the last decade as important premalignant lesions
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …

Colorectal cancer had a low incidence several decades ago. However, it has become a
predominant cancer and now accounts for approximately 10% of cancer-related mortality in …

MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as
post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the …

Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …

Our understanding of serrated colorectal polyps has increased dramatically over the past
two decades and has led to a modern classification scheme for these lesions. Sessile …

Background The prevalence of sessile serrated adenomas and/or polyps (SSA/Ps) is
uncertain. Objective To determine the prevalence of SSA/Ps and SSA/Ps with cytologic …

Until 2010, colorectal serrated lesions were generally considered as harmless lesions and
reported as hyperplastic polyps (HPs) by pathologists and gastroenterologists. However …