The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering
the body via the gut, the liver appears designed to detect, capture, and clear bacteria …

Endothelial cells that line capillaries are not just passive conduits for delivering blood.
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …

The aim of this review is to give an outline of the blood clearance function of the liver
sinusoidal endothelial cells (LSECs) in health and disease. Lining the hundreds of millions …

Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of
an organized basement membrane not only precedes fibrosis, but is also permissive for …

Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

Hyaluronan is a straight chain, glycosaminoglycan polymer of the extracellular matrix
composed of repeating units of the disaccharide [-d-glucuronic acid-β1, 3-N-acetyl-d …

Background Much of our current understanding of microvascular permeability is based on
the findings of classic experimental studies of blood capillary permeability to various-sized …

Recent advances in defining the molecular signaling pathways that regulate the
phagocytosis of apoptotic cells have improved our understanding of this complex and …

Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG) localized to
the cell surface and the tissue extracellular matrix (ECM). It is composed of disaccharides …

Liver fibrosis is a common feature of sustained liver injury and represents a major public
health problem worldwide. Fibrosis is an active research field and discoveries in the last …