Targeting galectin-driven regulatory circuits in cancer and fibrosis

KV Mariño, AJ Cagnoni, DO Croci… - Nature Reviews Drug …, 2023 - nature.com
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Dynamic contrast enhanced magnetic resonance imaging in oncology: theory, data acquisition, analysis, and examples

TE Yankeelov, JC Gore - Current Medical Imaging, 2007 - ingentaconnect.com
Dynamic contrast enhanced MRI (DCE-MRI) enables the quantitative assessment of tumor
status and has found application in both pre-clinical tumor models as well as clinical …

Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models

H Kim, E George, RL Ragland, S Rafail, R Zhang… - Clinical Cancer …, 2017 - AACR
Purpose: PARP inhibition (PARPi) has modest clinical activity in recurrent BRCA-mutant
(BRCA MUT) high-grade serous ovarian cancers (HGSOC). We hypothesized that PARPi …

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

VLJL Thijssen, R Postel, RJ Brandwijk… - Proceedings of the …, 2006 - National Acad Sciences
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and
that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells …

Current methods for assaying angiogenesis in vitro and in vivo

CA Staton, SM Stribbling, S Tazzyman… - International journal …, 2004 - Wiley Online Library
Angiogenesis, the development of new blood vessels from an existing vasculature, is
essential in normal developmental processes and in numerous pathologies, including …

Unraveling galectin-1 as a novel therapeutic target for cancer

L Astorgues-Xerri, ME Riveiro… - Cancer treatment …, 2014 - Elsevier
Galectins belong to a family of carbohydrate-binding proteins with an affinity for β-
galactosides. Galectin-1 is differentially expressed by various normal and pathologic tissues …

Galectins as molecular targets for therapeutic intervention

RPM Dings, MC Miller, RJ Griffin, KH Mayo - International journal of …, 2018 - mdpi.com
Galectins are a family of small, highly conserved, molecular effectors that mediate various
biological processes, including chemotaxis and angiogenesis, and that function by …

Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization

RPM Dings, M Loren, H Heun, E McNiel… - Clinical Cancer …, 2007 - AACR
Purpose: To test whether a direct antiangiogenic peptide (anginex) and a vascular
endothelial growth factor antibody (bevacizumab, Avastin) can transiently normalize …

Anti‐angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte‐endothelium interactions and infiltration in tumors

AEM Dirkx, MGA Egbrink, K Castermans… - The FASEB …, 2006 - Wiley Online Library
Tumor escape from immunity, as well as the failure of several anti‐cancer vaccination and
cellular immunotherapy approaches, is suggested to be due to the angiogenesis‐mediated …

Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature

JR Van Beijnum, RP Dings, E Van Der Linden… - Blood, 2006 - ashpublications.org
Crucial to designing angiostatic and vascular targeting agents is the identification of target
molecules. Because angiogenesis is not limited to pathologic conditions, careful evaluation …