Intracellular fluid mechanics: Coupling cytoplasmic flow with active cytoskeletal gel

A Mogilner, A Manhart - Annual Review of Fluid Mechanics, 2018 - annualreviews.org
The cell is a mechanical machine, and continuum mechanics of the fluid cytoplasm and the
viscoelastic deforming cytoskeleton play key roles in cell physiology. We review …

Nonlinear elastic and inelastic properties of cells

W Jung, J Li, O Chaudhuri… - Journal of …, 2020 - asmedigitalcollection.asme.org
Mechanical forces play an important role in various physiological processes, such as
morphogenesis, cytokinesis, and migration. Thus, in order to illuminate mechanisms …

Mechanics of motility initiation and motility arrest in crawling cells

P Recho, T Putelat, L Truskinovsky - Journal of the Mechanics and Physics …, 2015 - Elsevier
Motility initiation in crawling cells requires transformation of a symmetric state into a
polarized state. In contrast, motility arrest is associated with re-symmetrization of the internal …

Modelling the rheology of living cell cytoplasm: poroviscoelasticity and fluid-to-solid transition

N Thekkethil, J Köry, M Guo, PS Stewart, NA Hill… - … and Modeling in …, 2024 - Springer
Eukaryotic cell rheology has important consequences for vital processes such as adhesion,
migration, and differentiation. Experiments indicate that cell cytoplasm can exhibit both …

On the generation of force required for actin-based motility

A Salvadori, C Bonanno, M Serpelloni… - Scientific Reports, 2024 - nature.com
The fundamental question of how forces are generated in a motile cell, a lamellipodium, and
a comet tail is the subject of this note. It is now well established that cellular motility results …

Chemo-mechanical model of a cell as a stochastic active gel

V Deshpande, A DeSimone, R McMeeking… - Journal of the Mechanics …, 2021 - Elsevier
While it is commonly observed that the shape dynamics of mammalian cells can undergo
large random fluctuations, theoretical models aiming at capturing cell mechanics often focus …

A thin-film extensional flow model for biofilm expansion by sliding motility

A Tam, JEF Green, S Balasuriya… - … of the Royal …, 2019 - royalsocietypublishing.org
In the presence of glycoproteins, bacterial and yeast biofilms are hypothesized to expand by
sliding motility. This involves a sheet of cells spreading as a unit, facilitated by cell …

Nonlinear stress relaxation of transiently crosslinked biopolymer networks

S Chen, CP Broedersz, T Markovich, FC MacKintosh - Physical Review E, 2021 - APS
A long-standing puzzle in the rheology of living cells is the origin of the experimentally
observed long-time stress relaxation. The mechanics of the cell is largely dictated by the …

Mechanical perspective on chemotaxis

C Giverso, L Preziosi - Physical Review E, 2018 - APS
Cell motion in response to external chemical cues (chemotaxis) is a fundamental step in
many physiological and pathological phenomena. The ability of cells to move onto two …

Multiscale Modelling of the Poroviscoelastic Rheology of Cell Cytoplasm

N Thekkethil, K Jakub, M Guo, PS Stewart, NA Hill… - 2023 - researchsquare.com
Eukaryotic cell rheology has important consequences for vital processes such as adhesion,
migration, and differentiation. Experiments indicate that cell cytoplasm can exhibit both …