Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

[HTML][HTML] Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research

S Rakusanova, O Fiehn, T Cajka - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Current metabolomics and lipidomics studies are limited in the number of examined
matrices, the breadth and scope of methods, reporting the number of metabolites, and data …

MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation

Z Pang, Y Lu, G Zhou, F Hui, L Xu, C Viau… - Nucleic Acids …, 2024 - academic.oup.com
We introduce MetaboAnalyst version 6.0 as a unified platform for processing, analyzing, and
interpreting data from targeted as well as untargeted metabolomics studies using liquid …

Recent advances in mass spectrometry-based computational metabolomics

TMD Ebbels, JJJ van der Hooft, H Chatelaine… - Current opinion in …, 2023 - Elsevier
The computational metabolomics field brings together computer scientists, bioinformaticians,
chemists, clinicians, and biologists to maximize the impact of metabolomics across a wide …

New advances in tissue metabolomics: a review

M Saoi, P Britz-McKibbin - Metabolites, 2021 - mdpi.com
Metabolomics offers a hypothesis-generating approach for biomarker discovery in clinical
medicine while also providing better understanding of the underlying mechanisms of chronic …

PeakDecoder enables machine learning-based metabolite annotation and accurate profiling in multidimensional mass spectrometry measurements

A Bilbao, N Munoz, J Kim, DJ Orton, Y Gao… - Nature …, 2023 - nature.com
Multidimensional measurements using state-of-the-art separations and mass spectrometry
provide advantages in untargeted metabolomics analyses for studying biological and …

Data acquisition methods for non-targeted screening in environmental analysis

Y Yang, L Yang, M Zheng, D Cao, G Liu - TrAC Trends in Analytical …, 2023 - Elsevier
Human production and consumption activities lead to vastly release of numerous chemicals
into environments. Non-targeted screening methods are powerful tools for identifying huge …

Precise metabolomics reveals a diversity of aging‐associated metabolic features

H Tian, Z Ni, SM Lam, W Jiang, F Li, J Du… - Small …, 2022 - Wiley Online Library
Mass spectrometry‐based metabolomics has emerged as a powerful technique for
biomedical research, although technical issues with its analytical precision and structural …

Addressing big data challenges in mass spectrometry-based metabolomics

J Guo, H Yu, S Xing, T Huan - Chemical Communications, 2022 - pubs.rsc.org
Advancements in computer science and software engineering have greatly facilitated mass
spectrometry (MS)-based untargeted metabolomics. Nowadays, gigabytes of metabolomics …

Mass spectrometry-based nontargeted and targeted analytical approaches in fingerprinting and metabolomics of food and agricultural research

Z Liu, M Zhang, P Chen, JM Harnly… - Journal of Agricultural …, 2022 - ACS Publications
Mass spectrometry (MS)-based techniques have been extensively applied in food and
agricultural research. This review aims to address the advances and applications of MS …