Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have
diverse pathological features. During the past decade, in-depth analyses of lung cancer …

The respiratory tract is a vital, intricate system for several important biological processes
including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-
dimensional in vitro human distal lung culture systems would strongly facilitate the …

Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000
people. People with CF experience multi-organ dysfunction resulting from aberrant …

The human lung plays vital roles in respiration, host defense, and basic physiology. Recent
technological advancements such as single-cell RNA sequencing and genetic lineage …

The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …

Current smoking is associated with increased risk of severe COVID-19, but it is not clear how
cigarette smoke (CS) exposure affects SARS-CoV-2 airway cell infection. We directly …

Airways are exposed to myriad environmental and damaging agents such as reactive
oxygen species (ROS), which also have physiological roles as signaling molecules that …

Rationale: Remodeling and loss of distal conducting airways, including preterminal and
terminal bronchioles (pre-TBs/TBs), underlie progressive airflow limitation in chronic …