Non-small-cell lung cancers: a heterogeneous set of diseases
Z Chen, CM Fillmore, PS Hammerman, CF Kim… - Nature Reviews …, 2014 - nature.com
Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have
diverse pathological features. During the past decade, in-depth analyses of lung cancer …
diverse pathological features. During the past decade, in-depth analyses of lung cancer …
Wnt signaling in lung development, regeneration, and disease progression
CJ Aros, CJ Pantoja, BN Gomperts - Communications biology, 2021 - nature.com
The respiratory tract is a vital, intricate system for several important biological processes
including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling …
including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling …
A spatially resolved atlas of the human lung characterizes a gland-associated immune niche
E Madissoon, AJ Oliver, V Kleshchevnikov… - Nature Genetics, 2023 - nature.com
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids
The distal lung contains terminal bronchioles and alveoli that facilitate gas exchange. Three-
dimensional in vitro human distal lung culture systems would strongly facilitate the …
dimensional in vitro human distal lung culture systems would strongly facilitate the …
Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition
Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000
people. People with CF experience multi-organ dysfunction resulting from aberrant …
people. People with CF experience multi-organ dysfunction resulting from aberrant …
A census of the lung: CellCards from LungMAP
The human lung plays vital roles in respiration, host defense, and basic physiology. Recent
technological advancements such as single-cell RNA sequencing and genetic lineage …
technological advancements such as single-cell RNA sequencing and genetic lineage …
Building and regenerating the lung cell by cell
JA Whitsett, TV Kalin, Y Xu… - Physiological …, 2019 - journals.physiology.org
The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …
[HTML][HTML] Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair response
Current smoking is associated with increased risk of severe COVID-19, but it is not clear how
cigarette smoke (CS) exposure affects SARS-CoV-2 airway cell infection. We directly …
cigarette smoke (CS) exposure affects SARS-CoV-2 airway cell infection. We directly …
Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling
MK Paul, B Bisht, DO Darmawan, R Chiou, VL Ha… - Cell stem cell, 2014 - cell.com
Airways are exposed to myriad environmental and damaging agents such as reactive
oxygen species (ROS), which also have physiological roles as signaling molecules that …
oxygen species (ROS), which also have physiological roles as signaling molecules that …
A unique cellular organization of human distal airways and its disarray in chronic obstructive pulmonary disease
Rationale: Remodeling and loss of distal conducting airways, including preterminal and
terminal bronchioles (pre-TBs/TBs), underlie progressive airflow limitation in chronic …
terminal bronchioles (pre-TBs/TBs), underlie progressive airflow limitation in chronic …