The transcription factor family activator protein 2 (TFAP2) is vital for regulating both
embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding …

Cytosine methylation in DNA constitutes an important epigenetic layer of transcriptional and
regulatory control in many eukaryotes. Profiling DNA methylation across the genome is …

The neoplastic transformation of cells and inflammation are processes that contribute to
tumor initiation. Recently, emerging evidence has suggested that epigenetic alterations are …

Abstract Purpose Hypermethylation of TFAP2E (AP-2E) is associated with the chemotherapy-
resistant in patients with colorectal cancer (CRC), but its implications on prognosis directly …

Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) is highly expressed in
renal proximal tubules, where it contributes to the control of cell proliferation and …

Chemotherapy is a mainstay of therapy for advanced gastric cancer (GC); however, owing to
drug resistances, the effectiveness of chemotherapy is not satisfactory for some patients with …

Neuroblastoma is a childhood malignancy originating from the sympathetic nervous system
and accounts for approximately 15% of all pediatric cancer-related deaths. To newly identify …

The acquisition of genetic-and epigenetic-abnormalities during transformation has been
recognized as the two fundamental factors that lead to tumorigenesis and determine the …

TFAP2E is a member of the activator protein‑2 transcription factor family and acts as a tumor
suppressor in several types of cancer. Downregulation of TFAP2E expression is significantly …

Retinoic acid receptor-related orphan receptor α (RORA) is a tumor-specific differentially
methylated region. RORA mRNA expression is frequently downregulated in colorectal …