Covalent lipid modifications anchor numerous signalling proteins to the cytoplasmic face of
the plasma membrane. These modifications mediate protein–membrane and protein …

Palmitoylation is unique among lipid modifications of proteins in that it is reversible and
regulable. Recent advances in the study of palmitoylation include the following: the …

The palmitoylation or S-acylation of at least some G protein α subunits is a dynamic process
that is regulated in vivo by the activation of associated receptors. Highly purified …

R egulator of G protein s ignaling (RGS) proteins are GTPase‐activating proteins that
modulate neurotransmitter and G protein signaling. RGS7 and its binding partners Gα and …

To establish the biological function of thioacylation (palmitoylation), we have studied the
heterotrimeric guanine nucleotide–binding protein (G protein) subunits of the pheromone …

Publisher Summary This chapter describes the procedures used to detect protein
palmitoylation. The protocols for metabolic radiolabeling of cells and for analysis of …

Cholesterol-rich membrane domains (eg, lipid rafts) are thought to act as molecular sorting
machines, capable of coordinating the organization of signal transduction pathways within …

Regulation and coordination of membrane trafficking is a central requirement for secretion,
endocytosis, cell division and transport between intracellular compartments. The molecular …

We studied the effects of the in vivo administration of interleukin-2 (IL-2)(at low doses)+ GM-
CSF in BALB/C mice injected intraperitoneally with LSTRA murine leukemic cell line in order …