Insulin-resistance is a characteristic feature of type 2 diabetes (T2D) and plays a major role
in the pathogenesis of this disease. Skeletal muscles are quantitatively the biggest glucose …

The known genetic variability (common DNA polymorphisms) does not account either for the
current epidemics of type 2 diabetes or for the family transmission of this disorder. However …

Ochratoxin A (OTA) is a powerful mycotoxin found in various foods and feedstuff,
responsible for subchronic and chronic toxicity, such as nephrotoxicity, hepatotoxicity …

Peroxisome proliferator-activated receptor (PPAR)-α activation controls hepatic lipid
homeostasis, stimulating fatty acid oxidation, and adapting the metabolic response to lipid …

Exposure to endocrine-disrupting chemicals such as Bisphenol-A (BPA) is associated with
an increase in obesity prevalence. Diet is the primary cause of human exposure to this …

Hepatic de-novo lipogenesis and production of triglyceride rich very low density lipoprotein
(VLDL) is increased in the state of insulin resistance, however, the role of a negative …

Сахарный диабет 2 типа (СД2) является социально-значимым заболеванием, терапия
которого остается все еще недостаточно эффективной, отчасти это обусловлено …

Similarly to genetic polymorphisms, epigenetic modifications may alter transcriptional activity
and contribute to different traits of the Type 2 diabetes phenotype. The establishment of …

Aging exacerbates neointimal formation by reducing apoptosis of vascular smooth muscle
cells (VSMCs) and induces inflammation within vascular wall. Prep1 is a homeodomain …

Resistance toward imatinib (IM) and other BCR/ABL tyrosine kinase inhibitors remains
troublesome in the treatment of advanced stage chronic myeloid leukemia (CML). The aim of …