Nasally inhaled therapeutics and vaccination for COVID‐19: Developments and challenges
J Xi, LR Lei, W Zouzas, X April Si - MedComm, 2021 - Wiley Online Library
The nose is the initial site of viral infection, replication, and transmission in the human body.
Nasally inhaled vaccines may act as a promising alternative for COVID‐19 management in …
Nasally inhaled vaccines may act as a promising alternative for COVID‐19 management in …
Convolutions in the rendition of nose to brain therapeutics from bench to bedside: Feats & fallacies
Brain, a subtle organ of multifarious nature presents plethora of physiological, metabolic and
bio-chemical convolutions that impede the delivery of biomolecules and thereby resulting in …
bio-chemical convolutions that impede the delivery of biomolecules and thereby resulting in …
Visualization and estimation of nasal spray delivery to olfactory mucosa in an image-based transparent nasal model
Background: Nose-to-brain (N2B) drug delivery offers unique advantages over intravenous
methods; however, the delivery efficiency to the olfactory region using conventional nasal …
methods; however, the delivery efficiency to the olfactory region using conventional nasal …
Effect of MDI actuation timing on inhalation dosimetry in a human respiratory tract model
Accurate knowledge of the delivery of locally acting drug products, such as metered-dose
inhaler (MDI) formulations, to large and small airways is essential to develop reliable in …
inhaler (MDI) formulations, to large and small airways is essential to develop reliable in …
Optimized gravity-driven intranasal drop administration delivers significant doses to the ostiomeatal complex and maxillary sinus
Chronic and allergic rhinosinusitis impacts approximately 12% of the global population.
Challenges in rhinosinusitis treatment include paranasal sinus inaccessibility and variability …
Challenges in rhinosinusitis treatment include paranasal sinus inaccessibility and variability …
Liquid film translocation significantly enhances nasal spray delivery to olfactory region: A numerical simulation study
Previous in vivo and ex vivo studies have tested nasal sprays with varying head positions to
enhance the olfactory delivery; however, such studies often suffered from a lack of …
enhance the olfactory delivery; however, such studies often suffered from a lack of …
Effects of guiding vanes and orifice jet flow of a metered-dose inhaler on drug dosimetry in human respiratory tract
Accurate modeling and simulation of metered-dose inhaler (MDI) drug delivery require
detailed information about the spray aerosols and carrier airflows, which are sensitive to the …
detailed information about the spray aerosols and carrier airflows, which are sensitive to the …
Development and challenges of nasal spray vaccines for short-term COVID-19 protection
J Xi - Current Pharmaceutical Biotechnology, 2022 - ingentaconnect.com
For those who have traveled by flight during this pandemic and been seated in a packed
cabin for an extended period, it is natural to worry about the elevated risk of COVID-19 …
cabin for an extended period, it is natural to worry about the elevated risk of COVID-19 …
Characterizing regional drug delivery within the nasal airways
Introduction The nose has been receiving increased attention as a route for drug delivery. As
the site of deposition constitutes the first point of contact of the body with the drug …
the site of deposition constitutes the first point of contact of the body with the drug …
Stability study of spray freeze-dried insulin dry powder formulations used for nose-to-brain delivery
Insulin is classified as a cold chain product due to being a peptide hormone with stability
issues in the liquid preparation. Therefore, insulin was developed into the dry powder form …
issues in the liquid preparation. Therefore, insulin was developed into the dry powder form …