Viral persistence, reactivation, and mechanisms of long COVID

B Chen, B Julg, S Mohandas, SB Bradfute - Elife, 2023 - elifesciences.org
The COVID-19 global pandemic caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection has infected hundreds of millions of individuals …

[HTML][HTML] ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

AL Komaroff, WI Lipkin - Frontiers in Medicine, 2023 - frontiersin.org
Some patients remain unwell for months after “recovering” from the acute COVID-19. They
develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and …

Distinguishing features of Long COVID identified through immune profiling

J Klein, J Wood, JR Jaycox, RM Dhodapkar, P Lu… - Nature, 2023 - nature.com
Post-acute infection syndromes may develop after acute viral disease. Infection with SARS-
CoV-2 can result in the development of a post-acute infection syndrome known as long …

[HTML][HTML] Muscle abnormalities worsen after post-exertional malaise in long COVID

B Appelman, BT Charlton, RP Goulding… - Nature …, 2024 - nature.com
A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months
after infection. A distinctive symptom of patients with long COVID is post-exertional malaise …

Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

MJ Peluso, D Ryder, RR Flavell, Y Wang… - Science translational …, 2024 - science.org
The mechanisms of postacute medical conditions and unexplained symptoms after SARS-
CoV-2 infection [Long Covid (LC)] are incompletely understood. There is growing evidence …

[HTML][HTML] Fibrin drives thromboinflammation and neuropathology in COVID-19

JK Ryu, Z Yan, M Montano, EG Sozmen, K Dixit… - Nature, 2024 - nature.com
Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19
and are persistent in patients with long COVID experiencing post-acute sequelae of SARS …

The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID

J Li, Y Zhou, J Ma, Q Zhang, J Shao, S Liang… - … and Targeted Therapy, 2023 - nature.com
There have been hundreds of millions of cases of coronavirus disease 2019 (COVID-19),
which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With …

Long COVID: major findings, mechanisms and recommendations

HE Davis, L McCorkell, JM Vogel… - Nature Reviews …, 2023 - nature.com
Long COVID is an often debilitating illness that occurs in at least 10% of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms …

Long COVID: a review and proposed visualization of the complexity of long COVID

R Perumal, L Shunmugam, K Naidoo… - Frontiers in …, 2023 - frontiersin.org
Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus–2 (SARS-CoV-2)
infection, or Long COVID, is a prevailing second pandemic with nearly 100 million affected …

Prevalence of persistent SARS-CoV-2 in a large community surveillance study

M Ghafari, M Hall, T Golubchik, D Ayoubkhani, T House… - Nature, 2024 - nature.com
Persistent SARS-CoV-2 infections may act as viral reservoirs that could seed future
outbreaks,,,–, give rise to highly divergent lineages,–and contribute to cases with post-acute …