The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …

Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly
understood. Here we report the massively parallel sequencing of 38 tumour genomes and …

From the earliest comparisons of RNA production with steady-state levels, it has been clear
that cells transcribe more RNA than they accumulate, implying the existence of active RNA …

The multisubunit RNA exosome complex is a major ribonuclease of eukaryotic cells that
participates in the processing, quality control and degradation of virtually all classes of RNA …

The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …

Highlights•Eukaryotic exosome cores and phosphorolytic exoribonucleases are structurally
similar.•Exosome cores include a central channel but are catalytically inert.•Central channel …

Eukaryotic cells contain numerous RNA quality-control systems that are important for
shaping the transcriptome of eukaryotic cells. These systems not only prevent accumulation …

Perlman syndrome is a congenital overgrowth syndrome inherited in an autosomal
recessive manner that is associated with Wilms tumor susceptibility. We mapped a …

The mechanisms of gene expression regulation by miRNAs have been extensively studied.
However, the regulation of miRNA function and decay has long remained enigmatic. Only …