Gene drives may be capable of addressing ecological problems by altering entire
populations of wild organisms, but their use has remained largely theoretical due to …

Because of the particular characteristics of the tumor microenvironment and tumor
angiogenesis, it is possible to design drug delivery systems that specifically target anti …

Herein, we have developed nanohybrids (nHs) to remotely activate a therapeutic enzyme for
its use in Directed Enzyme Prodrug Therapy (DEPT). The coencapsulation of magnetic …

Self‐immolative spacers are covalent assemblies tailored to correlate the cleavage of two
chemical bonds after activation of a protective part in a precursor: Upon stimulation, the …

It is estimated that about 10% of the drugs approved worldwide can be classified as
prodrugs. Prodrugs, which have no or poor biological activity, are chemically modified …

In this extensive review, we elucidate the importance of proteases and their role in drug
development in various diseases with an emphasis on cancer. First, key proteases are …

Drug action is inherently multiscale: it connects molecular interactions to emergent
properties at cellular and larger scales. Simulation techniques at each of these different …

Antibody directed enzyme prodrug therapy has the potential to be an effective therapy for
most common solid cancers. Clinical studies with CPG2 system have shown the feasibility of …

Background Until recently, patients who have the same type and stage of cancer all receive
the same treatment. It has been established, however, that individuals with the same …

The strategy of using mesenchymal stem cells (MSCs) as a living carrier for active delivery of
therapeutic agents targeting tumor sites has been attempted in a wide range of studies to …