Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …

The idea of antiangiogenic therapy was the brainchild of D r. J udah F olkman in the early
1970s. He proposed that by cutting off the blood supply, cancer cells would be deprived of …

Netrin-1 is upregulated in cancers as a protumoural mechanism. Here we describe netrin-1
upregulation in a majority of human endometrial carcinomas (ECs) and demonstrate that …

The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide
gene. Achieving the same using small molecules would have a tremendous impact on …

Drug resistance and cancer relapse represent significant therapeutic challenges after
chemotherapy or immunotherapy, and a major limiting factor for long-term cancer survival …

Dependence receptors (DRs) now form a family of more than a dozen membrane receptors
that are not linked by their structure, but by common functional traits. The most notable is …

Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism
to allow these tumors to escape the pro-apoptotic activity of some of its main dependence …

The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-
1, and this is important for neuronal and vascular development and for limitation of cancer …

Netrin-1 is a bifunctional chemotropic guidance cue that plays key roles in diverse cellular
processes including axon pathfinding, cell migration, adhesion, differentiation, and survival …

Netrin-1 was recently proposed to play an important role in embryonic and pathological
angiogenesis. However, data reported led to the apparently contradictory conclusions that …