[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19

RT Eastman, JS Roth, KR Brimacombe… - ACS central …, 2020 - ACS Publications
The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven
the biomedical community to action—to uncover and develop antiviral interventions. One …

[HTML][HTML] The proteins of severe acute respiratory syndrome coronavirus-2 (SARS CoV-2 or n-COV19), the cause of COVID-19

FK Yoshimoto - The protein journal, 2020 - Springer
The devastating effects of the recent global pandemic (termed COVID-19 for “coronavirus
disease 2019”) caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV …

Toward nanotechnology-enabled approaches against the COVID-19 pandemic

C Weiss, M Carriere, L Fusco, I Capua… - ACS …, 2020 - ACS Publications
The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment
as well as mitigation of the spread of infection, all through large-scale approaches such as …

[HTML][HTML] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier… - Nature, 2020 - nature.com
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development

N Murgolo, AG Therien, B Howell, D Klein… - Advances in Clinical …, 2021 - taylorfrancis.com
Coronaviruses, named for their crown-like spiked surface, are genetically diverse and can
infect multiple animal species, including bats, pigs, cats, rodents, and humans. Aside from …

Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19

C Mirabelli, JW Wotring, CJ Zhang… - Proceedings of the …, 2021 - National Acad Sciences
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
and the associated disease COVID-19, requires therapeutic interventions that can be rapidly …

[HTML][HTML] COVID-19: Advances in diagnostic tools, treatment strategies, and vaccine development

M Sreepadmanabh, AK Sahu, A Chande - Journal of biosciences, 2020 - Springer
An unprecedented worldwide spread of the SARS-CoV-2 has imposed severe challenges
on healthcare facilities and medical infrastructure. The global research community faces …

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

R Poduri, G Joshi, G Jagadeesh - Cellular signalling, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense,
single-stranded RNA virus that causes the potentially lethal Covid-19 respiratory tract …

[PDF][PDF] Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication

G Garcia, A Sharma, A Ramaiah, C Sen, A Purkayastha… - Cell reports, 2021 - cell.com
SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. We developed a
medium-throughput drug-screening system and identified a small-molecule library of 34 of …