Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Metabolite lactic acid has always been regarded as a metabolic by-product rather than a
bioactive molecule. Recently, this view has changed since it was discovered that lactic acid …

The occurrence and development of tumors depend on the tumor microenvironment (TME),
which consists of various types of cellular and acellular components. Tumor-associated …

Macrophages are innate phagocytic leukocytes that are highly present in solid tumors,
where they are referred to as tumor-associated macrophages (TAMs). In solid tumors, the …

The Warburg effect, one of the hallmarks of tumors, produces large amounts of lactate and
generates an acidic tumor microenvironment via using glucose for glycolysis. As a …

Hypoxia and high accumulation of lactic acid in the tumor microenvironment provide fertile
soil for tumor development, maintenance and metastasis. Herein, we developed a calcium …

Lactic acid (LA) metabolism in the tumor microenvironment contributes to the establishment
and maintenance of immune tolerance. This pathway is characterized in tumor associated …

Aging disrupts the maintenance of liver homeostasis, which impairs hepatocyte regeneration
and aggravates acute liver injury (ALI), ultimately leading to the development of acute liver …

Background To investigate the effect of lactic acid (LA) on the progression of bone
metastasis from colorectal cancer (CRC) and its regulatory effects on primary CD115 (+) …

Resistance to anticancer therapeutics occurs in virtually every type of cancer and becomes a
major difficulty in cancer treatment. Although 5-fluorouracil (5FU) is the first-line choice of …