The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …

Regeneration of skeletal muscle is a highly synchronized process that requires muscle stem
cells (satellite cells). We found that localized injuries, as experienced through exercise …

MICU1 is a calcium (Ca2+)–binding protein that regulates the mitochondrial Ca2+ uniporter
channel complex (mtCU) and mitochondrial Ca2+ uptake. MICU1 knockout mice display …

Recently, the role of mitochondrial activity in high-energy demand organs and in the
orchestration of whole-body metabolism has received renewed attention. In mitochondria …

Age-related loss of skeletal muscle mass and function, termed sarcopenia, could impair the
quality of life in the elderly. The mechanisms involved in skeletal muscle aging are intricate …

Plasma membrane integrity is essential for cellular homeostasis. In vivo, cells experience
plasma membrane damage from a multitude of stressors in the extra-and intra-cellular …

Mitochondria are the primary source of energy production and are implicated in a wide
range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on …

Dysregulation of mitochondrial Ca2+ homeostasis has been linked to neurodegenerative
diseases. Mitochondrial Ca2+ uptake is mediated via the calcium uniporter complex that is …

Activating Ca2+-sensitive enzymes of oxidative metabolism while preventing calcium
overload that leads to mitochondrial and cellular injury requires dynamic control of …