Synopsis The central α 2 adrenoceptor agonist tizanidine is a myotonolytic agent used in the
treatment of spasticity in patients with cerebral or spinal injury. Wide interpatient variability in …

The past decade has witnessed rapid progress in defining neural circuits and mechanisms
in the brain, responsible for regulation of the sympathetic nerve activity and cardiovascular …

Meythaler JM, Guin-Renfroe S, Johnson A, Brunner RM. Prospective assessment of
tizanidine for spasticity due to acquired brain injury. Arch Phys Med Rehabil 2001; 82: 1155 …

Objective: Tizanidine is an imidazoline central α2-adrenoceptor agonist widely used to
manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and …

Abstract Effects of clonidine and tizanidine, which have antinociceptive and α 2-agonistic
actions, were studied on the release of substance P from slices of spinal cord from the rat …

Experiments in cats anesthetized with α-chloralose showed that tizanidine (TZD: 5-chloro-4-
(2-imidazolin-2-yl-amino)-2, 1, 3-benzothiodiazole) partly resembled carbamazepine (CBZ) …

Fibromyalgia (FM) is a chronic syndrome characterized mainly by widespread pain,
unrefreshing sleep, disturbed mood, and fatigue. It is a clinical syndrome involving a variety …

The pharmacokinetics of tizanidine, a new centrally acting muscle relaxant, have been
studied in 18 normal male volunteers who received orally a single 5 mg dose, a single 20 …

Chronic, widespread pain represents the sine qua non of the fibromyalgia syndrome (FMS),
a fact reflected in the requirements of the American College of Rheumatology's 1990 …

Background The intrathecal alpha2-adrenergic agonist, clonidine, has been shown to have
considerable antinociceptive effect, although clonidine causes hypotension and …