Bacterial two-component systems (TCS) are versatile signaling mechanisms that govern
cellular responses to diverse environmental cues. These systems rely on phosphoryl-group …

The signal transduction system of microorganisms helps them adapt to changes in their
complex living environment. Two-component system (TCS) is a representative signal …

Mucus is a densely populated ecological niche that coats all non-keratinized epithelia, and
plays a critical role in protecting the human body from infections. Although traditionally …

Bacterial signaling histidine kinases (HKs) have long been postulated to function exclusively
through linear signal transduction chains. However, several HKs have recently been shown …

Productive plant–bacteria interactions, either beneficial or pathogenic, require that bacteria
successfully sense, integrate and respond to continuously changing environmental and …

Bacterial biofilms (BFs) are membrane-like structures formed by the secretion of extracellular
polymeric substances (EPS) by bacteria. The formation of BFs contributes to bacterial …

CbrAB is a two-component system, unique to bacteria of the family Pseudomonaceae,
capable of integrating signals and involved in a multitude of physiological processes that …

The current work involves the use of dehydroacetic acid based chalcone derivatives for the
synthesis of spirooxindole grafted pyrrolidine moieties. All the synthesized compounds have …

The GacS histidine kinase is the membrane sensor of the major upstream two-component
system of the regulatory Gac/Rsm signal transduction pathway. This pathway governs the …

Histidine is a versatile residue playing key roles in enzyme catalysis thanks to the chemistry
of its imidazole group that can serve as nucleophile, general acid or base depending on its …