Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have
been under development since the first whole-genome sequences appeared in the mid …

The prediction of cellular function from a genotype is a fundamental goal in biology. For
metabolism, constraint-based modelling methods systematize biochemical, genetic and …

Metabolic networks are interconnected and influence diverse cellular processes. The protein-
metabolite interactions that mediate these networks are frequently low affinity and …

Precise quantification of metabolic pathway fluxes in biological systems is of major
importance in guiding efforts in metabolic engineering, biotechnology, microbiology, human …

Cancer metabolism is significantly altered from normal cellular metabolism allowing cancer
cells to adapt to changing microenvironments and maintain high rates of proliferation. In the …

The field of metabolic engineering is primarily concerned with improving the biological
production of value-added chemicals, fuels and pharmaceuticals through the design …

MAVEN is an open‐source software program for interactive processing of LC‐MS‐based
metabolomics data. MAVEN enables rapid and reliable metabolite quantitation from multiple …

Genome-scale metabolic models have proven to be valuable for predicting organism
phenotypes from genotypes. Yet efforts to develop new models are failing to keep pace with …

Metabolic engineering has been enabling development of high performance microbial
strains for the efficient production of natural and non-natural compounds from renewable …

The genome‐scale model (GEM) of metabolism in the bacterium Escherichia coli K‐12 has
been in development for over a decade and is now in wide use. GEM‐enabled studies of E …