The sarcomere is the basic contractile unit of striated muscle and is a highly ordered protein
complex with the actin and myosin filaments at its core. Assembling the sarcomere …

The lysosomes have definitely polished their status inside the cell. Being discovered as the
last resort of discarded cellular biomass, the steady rising of this versatile signaling …

The ubiquitin–proteasome system (UPS) plays a critical role in removing unwanted
intracellular proteins and is involved in protein quality control, signalling and cell death …

Rigorous surveillance of protein quality control is essential for the maintenance of normal
cardiac function, while the dysregulation of protein turnover is present in a diverse array of …

Aims The heart undergoes pathological remodelling, featured by the hypertrophic growth of
cardiomyocytes and increased cardiac fibrosis, under biomechanical stress such as …

During influenza A epidemics, bacterial coinfection is a major cause of increased morbidity
and mortality. However, the roles of host factors in regulating influenza A virus (IAV) …

Protein quality control (PQC) is essential to intracellular proteostasis and is carried out by
sophisticated collaboration between molecular chaperones and targeted protein …

Cathepsin G (CG), a neutrophil serine protease, induces cell migration and multicellular
aggregation of human breast cancer MCF‐7 cells in a process that is dependent on E …

High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with
few effective, targeted therapies. HGSOC tumors exhibit genomic instability with frequent …

Bone marrow (BM) holds a large reserve of polymorphonuclear neutrophils (PMNs) that are
rapidly mobilized to the circulation and tissues in response to danger signals. SerpinB1 is a …