From therapeutic drug monitoring to model‐informed precision dosing for antibiotics

SG Wicha, AG Märtson, EI Nielsen… - Clinical …, 2021 - Wiley Online Library
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: A revised consensus guideline and review by the American …

MJ Rybak, J Le, TP Lodise, DP Levine… - American Journal of …, 2020 - academic.oup.com
Methods These are the consensus statements and guideline of ASHP, IDSA, the Pediatric
Infectious Diseases Society (PIDS), and SIDP. Guideline panel composition consisted of …

Antimicrobial stewardship in the NICU

JB Cantey, SJ Patel - Infectious Disease Clinics, 2014 - id.theclinics.com
Antibiotics are the most commonly prescribed medications in neonatal intensive care units
(NICUs). 1 There is increasing evidence that inappropriate or excessive use of antibiotics in …

Are vancomycin trough concentrations adequate for optimal dosing?

MN Neely, G Youn, B Jones, RW Jelliffe… - Antimicrobial agents …, 2014 - Am Soc Microbiol
The current vancomycin therapeutic guidelines recommend the use of only trough
concentrations to manage the dosing of adults with Staphylococcus aureus infections. Both …

Association between vancomycin trough concentration and area under the concentration-time curve in neonates

A Frymoyer, AL Hersh, MH El-Komy… - Antimicrobial agents …, 2014 - Am Soc Microbiol
National treatment guidelines for invasive methicillin-resistant Staphylococcus aureus
(MRSA) infections recommend targeting a vancomycin 24-h area under the concentration …

Pneumococcal disease in the era of pneumococcal conjugate vaccine

I Yildirim, KM Shea, SI Pelton - Infectious Disease Clinics, 2015 - id.theclinics.com
The universal immunization of infants and toddlers with pneumococcal conjugate vaccine
(PCV) in the United States beginning in 2000 heralded a new era for pneumococcal disease …

Model-informed precision dosing of antibiotics in pediatric patients: a narrative review

A Abdulla, E Edwina, RB Flint, K Allegaert… - Frontiers in …, 2021 - frontiersin.org
Optimal pharmacotherapy in pediatric patients with suspected infections requires
understanding and integration of relevant data on the antibiotic, bacterial pathogen, and …

[图书][B] Nelson's pediatric antimicrobial therapy

JS Bradley - 2012 - publications.aap.org
Welcome to the 29th edition of Nelson's Pediatric Antimicrobial Therapy, the third edition
written during the COVID-19 pandemic, which continues to significantly affect our lives and …

Pharmacodynamic characteristics of nephrotoxicity associated with vancomycin use in children

J Le, P Ny, E Capparelli, J Lane, B Ngu… - Journal of the …, 2015 - academic.oup.com
Background Limited studies incorporating population-based pharmacokinetic modeling
have been conducted to determine pharmacodynamic indices associated with …

Nephrotoxicity with vancomycin in the pediatric population: a systematic review and meta-analysis

TM Fiorito, MK Luther, PH Dennehy… - The Pediatric …, 2018 - journals.lww.com
Background: Vancomycin is frequently used to treat methicillin-resistant Staphylococcus
aureus infections in pediatric patients. Vancomycin exposure may lead to an increase in …