Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: biological activity and structural …
Erratic cell proliferation is the initial symptom of cancer, which can eventually metastasize to
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
Current development of pyrazole–azole hybrids with anticancer potential
S Zhang, Y Ye, Q Zhang, Y Luo, ZC Wang… - Future Medicinal …, 2023 - Taylor & Francis
Chemotherapy is a critical treatment modality for cancer patients, but multidrug resistance
remains one of the major challenges in cancer therapy, creating an urgent need for the …
remains one of the major challenges in cancer therapy, creating an urgent need for the …
New naphthoquinone thiazole hybrids as carbonic anhydrase and cholinesterase inhibitors: Synthesis, crystal structure, molecular docking, and acid dissociation …
Abstract In this study, N-[3-(3-amino-1, 4-dioxo-1, 4-dihydronaphthalen-2-yl)-4-R-thiazol-2
(3H)-ylidene]-2, 6-difluorobenzamide derivatives as new 1, 4-naphthoquinone thiazole …
(3H)-ylidene]-2, 6-difluorobenzamide derivatives as new 1, 4-naphthoquinone thiazole …
Synthesis of Novel 2-((3-(Benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl-4-phenylthiazole: Potent EGFR Targeting Anticancer Agents
S Amudala, R Palabindela, S Bhoomandla… - Russian Journal of …, 2024 - Springer
Objective: Benzofurans, fused pyrazole systems, and thiazole moieties are the most
important pharmacophores and intermediates for making drugs. The preparation and anti …
important pharmacophores and intermediates for making drugs. The preparation and anti …
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
Cancer stands as one of the deadliest diseases, ranking second in terms of its global impact.
Despite the presence of numerous compelling theories concerning its origins, none have …
Despite the presence of numerous compelling theories concerning its origins, none have …
Advances in β‐Diketocyclisation of Curcumin Derivatives and their Antitumor Activity
H Dai, S Zhang, X Zheng, Z Luo… - Chemistry & …, 2024 - Wiley Online Library
Curcumin, derived from the popular spice turmeric, is a pharmacologically active
polyphenol. Curcumin's therapeutic activity has been extensively studied in recent decades …
polyphenol. Curcumin's therapeutic activity has been extensively studied in recent decades …
Targeting EGFR by Newer 1-(3, 5-Bis ((E)-4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)-2-((substituted phenyl) amino) ethan-1-one Analogues for the Treatment of …
Several curcumin analogues (C01-C03) were prepared in green solvent (water-glycerol; 2: 1
v/v) with boric acid (10% mol solution in glycerol). All the compounds were characterized by …
v/v) with boric acid (10% mol solution in glycerol). All the compounds were characterized by …
Synthesis, docking studies, in silico ADMET predictions, DFT calculations, and photophysical properties of thiazole-anthracene hybrids as potent EGFR inhibitors
R Palabindela, R Bodapati, P Myadaraveni… - Journal of Molecular …, 2024 - Elsevier
The thiazole ring closure of thiosemicarbazones with α-bromo-4-substituted acetophenones
was carried out to generate aminothiazole analogues (A1–A16). Experimental methods …
was carried out to generate aminothiazole analogues (A1–A16). Experimental methods …
Current scenario of pyrazole hybrids with anti‐breast cancer therapeutic applications
M Ma - Archiv der Pharmazie, 2024 - Wiley Online Library
Breast cancer stands as the leading cause of cancer‐related deaths among women globally,
but current therapy is restricted to the serious adverse effects and multidrug resistance …
but current therapy is restricted to the serious adverse effects and multidrug resistance …
Synthesis, structure determination, molecular interaction, optical, thermal and anticancer activity studies, pharmacokinetic evaluation, and in-silico analysis of …
AA Fathima, DR Jonathan, R Yuvashri… - Journal of Molecular …, 2024 - Elsevier
Overseeing the diverse pharmacological traits of curcumin, a novel monocarbonyl based
curcumin derivative (1-(4-ethylbenzoyl)-3, 5-bis ((E)-4-methoxybenzylidene) piperidin-4 …
curcumin derivative (1-(4-ethylbenzoyl)-3, 5-bis ((E)-4-methoxybenzylidene) piperidin-4 …