Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the
skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue …

Pulmonary hypertension is defined as a resting mean pulmonary artery pressure of 25 mm
Hg or above. This review deals with pulmonary arterial hypertension (PAH), a type of …

Perivascular inflammation is a prominent pathologic feature in most animal models of
pulmonary hypertension (PH) as well as in pulmonary arterial hypertension (PAH) patients …

This review summarizes an expanding body of knowledge indicating that failure to resolve
inflammation and altered immune processes underlie the development of pulmonary arterial …

Pulmonary hypertension (PH) is a feature of a variety of diseases and continues to harbor
high morbidity and mortality. The main consequence of PH is right-sided heart failure which …

In the last few months, the number of cases of a new coronavirus-related disease (COVID-
19) rose exponentially, reaching the status of a pandemic. Interestingly, early imaging …

Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate.
However, fundamental gaps remain in our understanding of the underlying pathological …

Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension
and involves changes in the intima, media and adventitia, often with the interplay of …

Pulmonary hypertension (PH) describes heterogeneous population of patients with a mean
pulmonary arterial pressure> 20 mm Hg. Rarely, PH presents as a primary disorder but is …

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung
endothelial cell dysfunction and vascular remodeling. Normally, the endothelium forms an …