Simple Summary Colorectal cancer (CRC) is the second-leading cause of cancer-related
deaths worldwide. In this review article, we examine the role of gut microbiota in the …

Background Analysis of circulating tumour DNA could stratify cancer risk in symptomatic
patients. We aimed to evaluate the performance of a methylation-based multicancer early …

Background Colorectal cancer (CRC) incidence and mortality are increasing internationally.
Endoscopy services are under significant pressure with many overwhelmed. Faecal …

Background Faecal immunochemical test (FIT) usage for symptomatic patients is increasing,
but variations in use caused by sociodemographic factors are unknown. A clinical pathway …

Background Faecal immunochemical test (FIT)-directed pathways based on a single test
have been implemented for symptomatic patients. However, with a single test, the sensitivity …

Key developments in early diagnosis research and policy since the publication of the highly
cited BJC review “Is increased time to diagnosis and treatment associated with poorer …

Colorectal cancer (CRC) is the third most common cancer worldwide, and the second
commonest cause of cancer deaths worldwide. One of the most important prognostic factors …

Faecal hemoglobin concentrations (f-Hb) can be quantitated using faecal immunochemical
test for haemoglobin (FIT) analytical systems. FIT are of proven value and widely used in …

(1) Background: Colorectal cancer is the second commonest cause of cancer deaths
worldwide; recently, volatile organic compounds (VOCs) have been proposed as potential …

We aimed to develop and validate prediction models incorporating demographics, clinical
features, and a weighted genetic risk score (wGRS) for individual prediction of colorectal …