The ankyrin repeat is one of the most frequently observed amino acid motifs in protein
databases. This protein–protein interaction module is involved in a diverse set of cellular …

P16INK4A (also known as P16 and MTS1), a protein consisting exclusively of four ankyrin
repeats, is recognized as a tumor suppressor mainly because of the prevalence of genetic …

A large proportion of human melanomas harbor a mutation leading to permanent activation
of the serine/threonine kinase BRAF, and as a consequence, they have developed …

Mutations or deletions in the cyclin-dependent kinase inhibitor p16 INK4A are associated
with multiple cancer types, but are more commonly found in melanoma tumors and …

The human genome contains frequent single‐basepair variants that may or may not cause
genetic disease. To characterize benign vs. pathogenic missense variants, numerous …

Inherited predisposition to disease is often linked to reduced activity of a disease associated
gene product. Thus, quantitation of the influence of inherited variants on gene function can …

Watercress is an enriched source of phenethyl isothiocyanate (PEITC), among other
phytochemicals, with an antioxidant capacity. The aim of this study was to (i) chemically …

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Early
detection of CRC can significantly reduce this mortality rate. Unfortunately, recommended …

Genetic alterations in the INK4a/ARF (or CDKN2A) locus have been reported in many
cancer types, including melanoma; head and neck squamous cell carcinomas; lung, breast …

Malignant neoplasms, including pancreatic cancer and melanoma, are major global health
challenges. This study investigates melanoma pancreatic syndrome, a rare hereditary tumor …