The role of integration in oncogenic progression of HPV-associated cancers
AA McBride, A Warburton - PLoS pathogens, 2017 - journals.plos.org
Persistent infection with a subset of “high oncogenic risk” human papillomaviruses (HPVs)
can promote the development of cancer. In these cancers, the extrachromosomal viral …
can promote the development of cancer. In these cancers, the extrachromosomal viral …
High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis
Infection with high-risk human papillomavirus (HPV) has been linked to several human
cancers, the most prominent of which is cervical cancer. The integration of the viral genome …
cancers, the most prominent of which is cervical cancer. The integration of the viral genome …
Understanding the HPV integration and its progression to cervical cancer
MA Oyervides-Muñoz, AA Pérez-Maya… - Infection, Genetics and …, 2018 - Elsevier
Cervical cancer is one of the main causes of female cancer death worldwide, and human
papilloma virus (HPV) its causal agent. To investigate viral oncogenesis several studies …
papilloma virus (HPV) its causal agent. To investigate viral oncogenesis several studies …
Accuracy of HPV E6/E7 oncoprotein tests to detect high-grade cervical lesions: a systematic literature review and meta-analysis
L Downham, I Jaafar, ML Rol, V Nyawira Nyaga… - British Journal of …, 2024 - nature.com
Background Cervical carcinogenesis is mediated by the HPV-E6 and E7 oncoproteins,
considered as biomarkers usable in managing screen-positive women. Methods We …
considered as biomarkers usable in managing screen-positive women. Methods We …
Cervical cancer stem cells selectively overexpress HPV oncoprotein E6 that controls stemness and self-renewal through upregulation of HES1
Purpose: Perturbation of keratinocyte differentiation by E6/E7 oncoproteins of high-risk
human papillomaviruses that drive oncogenic transformation of cells in squamocolumnar …
human papillomaviruses that drive oncogenic transformation of cells in squamocolumnar …
Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis
Background Present study provides clinical evidence of existence of a functional loop
involving miR-21 and let-7a as potential regulators of aberrant STAT3 signaling recently …
involving miR-21 and let-7a as potential regulators of aberrant STAT3 signaling recently …
Regulation of cellular metabolism by high-risk human papillomaviruses
I Martínez-Ramírez, A Carrillo-García… - International journal of …, 2018 - mdpi.com
The alteration of glucose metabolism is one of the first biochemical characteristics
associated with cancer cells since most of these cells increase glucose consumption and …
associated with cancer cells since most of these cells increase glucose consumption and …
Insights into the mechanisms and structure of breakage-fusion-bridge cycles in cervical cancer using long-read sequencing
I Rodriguez, NM Rossi, AG Keskus, Y Xie… - The American Journal of …, 2024 - cell.com
Cervical cancer is caused by human papillomavirus (HPV) infection, has few approved
targeted therapeutics, and is the most common cause of cancer death in low-resource …
targeted therapeutics, and is the most common cause of cancer death in low-resource …
Dynamics of oral human papillomavirus infection in healthy population and head and neck cancer
NV Vani, R Madhanagopal, R Swaminathan… - Cancer …, 2023 - Wiley Online Library
The recent increase in high‐risk human papillomavirus (HR‐HPV)‐associated oral and
oropharyngeal cancers has gained considerable importance due to their distinct clinical and …
oropharyngeal cancers has gained considerable importance due to their distinct clinical and …
Proteases and HPV-induced carcinogenesis
GV Vieira, F Somera dos Santos, AP Lepique… - Cancers, 2022 - mdpi.com
Simple Summary Human papillomavirus (HPV) infection is a sexually transmitted disease
with high prevalence worldwide. Although most HPV infections do not lead to cancer, some …
with high prevalence worldwide. Although most HPV infections do not lead to cancer, some …