[HTML][HTML] What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2

SH Hodgson, K Mansatta, G Mallett, V Harris… - The lancet infectious …, 2021 - thelancet.com
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
has caused more than 1 million deaths in the first 6 months of the pandemic and huge …

The immunological mechanisms that control pneumococcal carriage

SP Jochems, JN Weiser, R Malley, DM Ferreira - PLoS pathogens, 2017 - journals.plos.org
Colonization of the human nasopharynx by pneumococcus is extremely common and is both
the primary reservoir for transmission and a prerequisite for disease. Current vaccines …

The PneuCarriage project: a multi-centre comparative study to identify the best serotyping methods for examining pneumococcal carriage in vaccine evaluation …

C Satzke, EM Dunne, BD Porter, KP Klugman… - PLoS …, 2015 - journals.plos.org
Background The pneumococcus is a diverse pathogen whose primary niche is the
nasopharynx. Over 90 different serotypes exist, and nasopharyngeal carriage of multiple …

Bivalent vaccine effectiveness against type-specific HPV positivity: evidence for cross-protection against oncogenic types among Dutch STI clinic visitors

PJ Woestenberg, AJ King… - The Journal of …, 2018 - academic.oup.com
Background Observational postmarketing studies are important to assess vaccine
effectiveness (VE). We estimated VE from the bivalent human papillomavirus (HPV) vaccine …

Upper respiratory tract colonization with Streptococcus pneumoniae in adults

A Arguedas, K Trzciński, KL O'Brien… - Expert review of …, 2020 - Taylor & Francis
Introduction Most of the current evidence regarding pneumococcal upper respiratory
colonization in adults suggests that despite high disease burden, carriage prevalence is low …

Experimental human pneumococcal carriage

JF Gritzfeld, AD Wright, AM Collins… - JoVE (Journal of …, 2013 - jove.com
Experimental human pneumococcal carriage (EHPC) is scientifically important because
nasopharyngeal carriage of Streptococcus pneumoniae is both the major source of …

Staphylococcus aureus vaccines: Deviating from the carol

D Missiakas, O Schneewind - Journal of Experimental Medicine, 2016 - rupress.org
Staphylococcus aureus, a commensal of the human nasopharynx and skin, also causes
invasive disease, most frequently skin and soft tissue infections. Invasive disease caused by …

A spitting image: molecular diagnostics applied to saliva enhance detection of Streptococcus pneumoniae and pneumococcal serotype carriage

WR Miellet, J van Veldhuizen, D Litt… - Frontiers in …, 2023 - frontiersin.org
Background Despite strong historical records on the accuracy of saliva testing, oral fluids are
considered poorly suited for pneumococcal carriage detection. We evaluated an approach …

Pneumococcal nasopharyngeal carriage in children< 5 years of age visiting the pediatric emergency room in relation to PCV7 and PCV13 introduction in southern …

S Ben-Shimol, N Givon-Lavi, D Greenberg… - Human vaccines & …, 2016 - Taylor & Francis
ABSTRACT The 7-valent and the 13-valent pneumococcal conjugate vaccines (PCV7 and
PCV13, respectively) were introduced to the Israeli National Immunization plan in July 2009 …

Rationale and prospects for novel pneumococcal vaccines

K Moffitt, R Malley - Human vaccines & immunotherapeutics, 2016 - Taylor & Francis
Streptococcus pneumoniae remains one of the most frequent bacterial causes of morbidity
and mortality worldwide. National immunization programs implementing pneumococcal …