Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis
as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still …

Despite being the hallmark of cancer that is responsible for the highest number of deaths,
very little is known about the biology of metastasis. Metastatic disease typically manifests …

Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major
factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways …

Brain metastasis is a major cause of cancer mortality, but its molecular mechanisms are
severely understudied. In addition, little is known regarding the role of m 6 A reader YTHDF3 …

As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various
homeostatic and pathological processes. These activities range from regulating embryonic …

Abstract Background Cancer stem cells (CSCs) are subpopulations of cancer cells sharing
similar characteristics as normal stem or progenitor cells such as self-renewal ability and …

Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

Metastases account for the great majority of cancer-associated deaths, yet this complex
process remains the least understood aspect of cancer biology. As the body of research …

The concept that progression of cancer is regulated by interactions of cancer cells with their
microenvironment was postulated by Stephen Paget over a century ago. Contemporary …