Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Cystathionine-β-synthase: molecular regulation and pharmacological inhibition

K Zuhra, F Augsburger, T Majtan, C Szabo - Biomolecules, 2020 - mdpi.com
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms

C Szabo, C Ransy, K Módis… - British journal of …, 2014 - Wiley Online Library
Until recently, hydrogen sulfide (H2S) was exclusively viewed a toxic gas and an
environmental hazard, with its toxicity primarily attributed to the inhibition of mitochondrial C …

Biological chemistry of hydrogen sulfide and persulfides

E Cuevasanta, MN Möller, B Alvarez - Archives of biochemistry and …, 2017 - Elsevier
Hydrogen sulfide (H 2 S) has been traditionally considered to be a toxic molecule for
mammals. However, it can be formed endogenously and exert physiological effects with …

The Torpid State: Recent Advances in Metabolic Adaptations and Protective Mechanisms

S Giroud, C Habold, RF Nespolo, C Mejías… - Frontiers in …, 2021 - frontiersin.org
Torpor and hibernation are powerful strategies enabling animals to survive periods of low
resource availability. The state of torpor results from an active and drastic reduction of an …

Bioinspired materials and technology for advanced cryopreservation

M Dou, C Lu, W Rao - Trends in Biotechnology, 2022 - cell.com
Cryopreservation can help to meet the demand for biosamples of high medical value.
However, it remains difficult to effectively cryopreserve some sensitive cells, tissues, and …

Hydrogen sulfide as an oxygen sensor

KR Olson - Antioxidants & redox signaling, 2015 - liebertpub.com
Abstract Significance: Although oxygen (O2)-sensing cells and tissues have been known for
decades, the identity of the O2-sensing mechanism has remained elusive. Evidence is …

H2S as a potential defense against COVID-19?

G Yang - American Journal of Physiology-Cell Physiology, 2020 - journals.physiology.org
The outbreak of COVID-19 pneumonia caused by a new coronavirus (severe acute
respiratory syndrome coronavirus 2, SARS-CoV-2) is posing a global health emergency and …

Recent advances in the role of endogenous hydrogen sulphide in cancer cells

HJ Chen, K Li, YZ Qin, JJ Zhou, T Li, L Qian… - Cell …, 2023 - Wiley Online Library
Hydrogen sulphide (H2S) is a gaseous neurotransmitter that can be self‐synthesized by
living organisms. With the deepening of research, the pathophysiological mechanisms of …

Mitochondrial metabolism in hibernation: regulation and implications

JF Staples, KE Mathers, BM Duffy - Physiology, 2022 - journals.physiology.org
Hibernators rapidly and reversibly suppress mitochondrial respiration and whole animal
metabolism. Posttranslational modifications likely regulate these mitochondrial changes …