Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Gastroesophageal reflux disease (GERD) is a condition in which gastric contents regurgitate
into the esophagus or beyond, resulting in either troublesome symptoms or complications …

Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have
since proven to be invaluable, safe, and effective agents for the management of a variety of …

Management of gastroesophageal reflux disease (GERD) commonly starts with an empiric
trial of proton pump inhibitor (PPI) therapy and complementary lifestyle measures, for …

Up to 40% of patients with symptoms suspicious of gastroesophageal reflux disease (GERD)
do not respond completely to proton pump inhibitor (PPI) therapy. The term “refractory …

Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for
the generation of library of enormous lead molecules. Owing to its vast pharmacological …

Background Proton pump inhibitors (PPI s) are widely used for the treatment of acid‐related
diseases. Vonoprazan is a member of a new class of acid suppressants; potassium …

Objective Since the publication of the Asia-Pacific consensus on gastro-oesophageal reflux
disease in 2008, there has been further scientific advancement in this field. This updated …

Background Persistent gastro‐oesophageal reflux disease (GERD) symptoms can occur
despite proton pump inhibitor (PPI) therapy. Aim To assess the prevalence and potential …

Patients with gastro-oesophageal reflux disease (GORD) who are not responding to proton
pump inhibitors (PPIs) given once daily are very common. Various underlying mechanisms …