Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …

Pancreatic cancer is a genetic disease, and the recurrent genetic alterations characteristic of
pancreatic cancer indicate the cellular processes that are targeted for malignant …

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

The tumour suppressor TP53 is mutated in the majority of human cancers, and in over 70%
of pancreatic ductal adenocarcinoma (PDAC),. Wild-type p53 accumulates in response to …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy and
estimated to become the second leading cause of cancer-related deaths by 2030. Although …

Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs)
are non-invasive neoplasms that are often observed in association with invasive pancreatic …

Due to its poor prognosis and the late stage at which it is typically diagnosed, early detection
of pancreatic cancer is a pressing clinical problem. Advances in genomic analysis of human …

Most adult carcinomas develop from noninvasive precursor lesions, a progression that is
supported by genetic analysis. However, the evolutionary and genetic relationships among …

Pancreatic cancer is one of the most lethal malignancies and is associated with a poor
prognosis. Surgery is considered the only potential curative treatment for pancreatic cancer …

Objective Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions that can
give rise to invasive pancreatic carcinoma. Although approximately 8% of patients with …