Metformin, a biguanide drug, is the most commonly used first-line medication for type 2
diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of …

Aims There is a close link between oxidative stress, inflammation, and type 2 diabetes
mellitus (T2DM). Gentisic acid (GA) is a di-phenolic compound and an active metabolite of …

Introduction Metformin poisoning with lactic acidosis is an uncommon yet clinically serious
condition related to the inhibition of normal aerobic metabolism. Toxicity may occur after an …

Background Metformin-associated lactic acidosis (MALA) is a rare event but
underrecognition may lead to unfavorable outcomes in type 2 diabetes patients. While many …

Introduction Metformin toxicity following therapeutic use or overdose may result in metabolic
acidosis with hyperlactatemia. This study aims to assess the relationship between serum …

Disorders of acid-base status are common in the critically ill and prompt recognition is
central to clinical decision making. The bicarbonate/carbon dioxide buffer system plays a …

Introduction Metformin-associated lactic acidosis is a well-described and commonly
encountered condition associated with significant morbidity and mortality. Patients with …

COVID-19, provoked by SARS-CoV-2, constitutes a global health issue with high rates of
mortality. The presence of diabetes mellitus is associated with severe coronavirus COVID-19 …

Diabetes mellitus (DM) is one of the most common chronic diseases; the worldwide
prevalence of DM in adults may be as high as 7.7%(439 million adults) by 2030. 1 As such …

Objectives: Summarize the pathophysiology leading to toxicity with metformin-associated
lactic acidosis. Review risk factors for developing metformin-associated lactic acidosis …