The State of the HIV Epidemic in the Philippines: Progress and Challenges in 2023

LMA Gangcuangco, PC Eustaquio - Tropical Medicine and Infectious …, 2023 - mdpi.com
In the past decade, the Philippines has gained notoriety as the country with the fastest-
growing human immunodeficiency virus (HIV) epidemic in the Western Pacific region. While …

[PDF][PDF] Excess weight gain with integrase inhibitors and tenofovir alafenamide: what is the mechanism and does it matter?

BR Wood, GD Huhn - Open forum infectious diseases, 2021 - academic.oup.com
Numerous studies have detected a greater likelihood of excess weight gain with specific
antiretrovirals (ARVs), particularly tenofovir alafenamide and integrase inhibitors, as …

Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2022 recommendations of the International Antiviral Society–USA panel

RT Gandhi, R Bedimo, JF Hoy, RJ Landovitz, DM Smith… - Jama, 2023 - jamanetwork.com
Importance Recent advances in treatment and prevention of HIV warrant updated
recommendations to guide optimal practice. Objective Based on a critical evaluation of new …

Integrase strand transfer inhibitors are associated with incident diabetes mellitus in people with human immunodeficiency virus

JA O'Halloran, J Sahrmann… - Clinical Infectious …, 2022 - academic.oup.com
Background Integrase strand transfer inhibitors (INSTIs) are associated with weight gain in
people with HIV (PWH). Less is known about the risk of other metabolic outcomes such as …

Weight gain after HIV therapy initiation: pathophysiology and implications

NC Chandiwana, MJ Siedner… - The Journal of …, 2024 - academic.oup.com
Rapid advances in the potency, safety, and availability of modern HIV antiretroviral therapy
(ART) have yielded a near-normal life expectancy for most people living with HIV (PLWH) …

[PDF][PDF] BHIVA guidelines on antiretroviral treatment for adults living with HIV-1 2022

L Waters, A Winston, I Reeves, M Boffito… - HIV …, 2022 - discovery.ucl.ac.uk
The overall purpose of these guidelines is to provide guidance on best clinical practice for
antiretroviral therapy (ART) and management of adults living with human immunodeficiency …

Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis with liver fibrosis as predictors of new-onset diabetes mellitus in people with HIV: A longitudinal …

WM Han, T Apornpong, HMS Lwin… - Clinical Infectious …, 2023 - academic.oup.com
Background We investigated the association between nonalcoholic fatty liver disease
(NAFLD) plus or minus a concurrent diagnosis of nonalcoholic steatohepatitis (NASH) and …

Impact of combined antiretroviral therapy on metabolic syndrome components in adult people living with HIV: A literature review

M Sapuła, M Suchacz, A Załęski, A Wiercińska-Drapało - Viruses, 2022 - mdpi.com
The development of metabolic derangements as a result of HIV treatment has been an
important area of research since the introduction of zidovudine in the 1980's. Antiretroviral …

Two-drug regimens for HIV treatment

KM Gibas, SG Kelly, JR Arribas, P Cahn, C Orkin… - The Lancet …, 2022 - thelancet.com
Combination therapy with three antiretroviral agents has been integral to successful HIV-1
treatment since 1996. Although the efficacy, adverse effects, and toxicities of contemporary …

Use of tenofovir alafenamide fumarate for HIV pre-exposure prophylaxis and incidence of hypertension and initiation of statins

AS Rivera, KJ Pak, MT Mefford… - JAMA Network Open, 2023 - jamanetwork.com
Importance Pre-exposure prophylaxis (PrEP) is an important tool for preventing HIV
infection. However, PrEP's impact on cardiometabolic health is understudied. Objective To …