Research on the role of reactive oxygen species (ROS) in the aging process has advanced
significantly over the last two decades. In light of recent findings, ROS takes part in the aging …

Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S) mouse …

Mitochondrial failure has long been associated with programmed axon death (Wallerian
degeneration, WD), a widespread and potentially preventable mechanism of axon …

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects
against redox stress by providing reducing equivalents to antioxidants such as glutathione …

Parkinson's disease (PD) is currently the second most common neurodegenerative disease,
being characterized by motor and non-motor symptoms. The therapeutic options available …

Parkinson's disease (PD) is a neurodegenerative disorder caused by the depletion of
dopaminergic neurons in the basal ganglia, the movement center of the brain …

We report an early-onset autosomal-recessive neurological disease with cerebellar atrophy
and lysosomal dysfunction. We identified bi-allelic loss-of-function (LoF) variants in …

Drosophila melanogaster is a valuable model organism for a wide range of biological
exploration. The well-known advantages of D. melanogaster include its relatively simple …

Parkinson's disease (PD) affects almost 1% of the population worldwide over the age of 50
years. Exposure to environmental toxins like paraquat and rotenone is a risk factor for …

Sterile α and toll/interleukin 1 receptor motif-containing protein 1 (SARM1) is the defining
molecule and central executioner of programmed axon death, also known as Wallerian …