Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …

This review article provides an overview of the different species that α‐synuclein aggregates
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

Parkinson's disease is characterized by the loss of nigrostriatal dopaminergic signaling and
the presence of alpha-synuclein aggregates (also called Lewy bodies and neurites) …

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

In a number of neurological diseases including Parkinson's disease (PD), α‑synuclein is
aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong …

Oligomeric species of various proteins are linked to the pathogenesis of different
neurodegenerative disorders. Consequently, there is intense focus on the discovery of novel …

The lack of disease-modifying treatments for neurodegenerative disease stems in part from
our rudimentary understanding of disease mechanisms and the paucity of targets for …

Parkinson's disease is an increasingly prevalent and currently incurable neurodegenerative
disorder. At the molecular level, this disease is characterized by the formation of aberrant …