[HTML][HTML] Pharmacological interventions for treatment of sarcopenia: current status of drug development for sarcopenia
JY Kwak, KS Kwon - Annals of geriatric medicine and research, 2019 - ncbi.nlm.nih.gov
Sarcopenia, the loss of skeletal muscle mass and function with age, was first recognized as
a disease in the International Classification of Diseases, Tenth Revision, Clinical …
a disease in the International Classification of Diseases, Tenth Revision, Clinical …
Biochemistry and biology of GDF11 and myostatin: similarities, differences, and questions for future investigation
RG Walker, T Poggioli, L Katsimpardi… - Circulation …, 2016 - Am Heart Assoc
Growth differentiation factor 11 (GDF11) and myostatin (or GDF8) are closely related
members of the transforming growth factor β superfamily and are often perceived to serve …
members of the transforming growth factor β superfamily and are often perceived to serve …
Brown adipose tissue controls skeletal muscle function via the secretion of myostatin
Skeletal muscle and brown adipose tissue (BAT) are functionally linked, as exercise
increases browning via secretion of myokines. It is unknown whether BAT affects muscle …
increases browning via secretion of myokines. It is unknown whether BAT affects muscle …
The genetics of bone mass and susceptibility to bone diseases
D Karasik, F Rivadeneira, ML Johnson - Nature Reviews Rheumatology, 2016 - nature.com
Osteoporosis is characterized by low bone mass and an increased risk of fracture. Genetic
factors, environmental factors and gene–environment interactions all contribute to a person's …
factors, environmental factors and gene–environment interactions all contribute to a person's …
The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control
S Imai - NPJ systems biology and applications, 2016 - nature.com
The original concept of the NAD World was proposed in 2009, providing a comprehensive
framework to investigate critical issues of biological robustness and trade-offs in mammalian …
framework to investigate critical issues of biological robustness and trade-offs in mammalian …
Similar sequences but dissimilar biological functions of GDF11 and myostatin
J Suh, YS Lee - Experimental & molecular medicine, 2020 - nature.com
Abstract Growth differentiation factor 11 (GDF11) and myostatin (MSTN) are closely related
TGFβ family members that are often believed to serve similar functions due to their high …
TGFβ family members that are often believed to serve similar functions due to their high …
Antimyostatin treatment in health and disease: The story of great expectations and limited success
TL Nielsen, J Vissing, TO Krag - Cells, 2021 - mdpi.com
In the past 20 years, myostatin, a negative regulator of muscle mass, has attracted attention
as a potential therapeutic target in muscular dystrophies and other conditions. Preclinical …
as a potential therapeutic target in muscular dystrophies and other conditions. Preclinical …
Myostatin deficiency not only prevents muscle wasting but also improves survival in septic mice
M Kobayashi, S Kasamatsu… - American Journal …, 2021 - journals.physiology.org
Sepsis remains a leading cause of mortality in critically ill patients. Muscle wasting is a major
complication of sepsis and negatively affects clinical outcomes. Despite intense …
complication of sepsis and negatively affects clinical outcomes. Despite intense …
Genetics of bone and muscle interactions in humans
K Trajanoska, F Rivadeneira, DP Kiel… - Current osteoporosis …, 2019 - Springer
Abstract Purpose of Review To summarize the evidence from recent studies on the shared
genetics between bone and muscle in humans. Recent Findings Genome-wide association …
genetics between bone and muscle in humans. Recent Findings Genome-wide association …
Widespread diversity in the transcriptomes of functionally divergent limb tendons
Key points Tendon is a hypocellular, matrix‐rich tissue that has been excluded from
comparative transcriptional atlases. These atlases have provided important knowledge …
comparative transcriptional atlases. These atlases have provided important knowledge …