[HTML][HTML] Pharmacological interventions for treatment of sarcopenia: current status of drug development for sarcopenia

JY Kwak, KS Kwon - Annals of geriatric medicine and research, 2019 - ncbi.nlm.nih.gov
Sarcopenia, the loss of skeletal muscle mass and function with age, was first recognized as
a disease in the International Classification of Diseases, Tenth Revision, Clinical …

Biochemistry and biology of GDF11 and myostatin: similarities, differences, and questions for future investigation

RG Walker, T Poggioli, L Katsimpardi… - Circulation …, 2016 - Am Heart Assoc
Growth differentiation factor 11 (GDF11) and myostatin (or GDF8) are closely related
members of the transforming growth factor β superfamily and are often perceived to serve …

Brown adipose tissue controls skeletal muscle function via the secretion of myostatin

X Kong, T Yao, P Zhou, L Kazak, D Tenen… - Cell metabolism, 2018 - cell.com
Skeletal muscle and brown adipose tissue (BAT) are functionally linked, as exercise
increases browning via secretion of myokines. It is unknown whether BAT affects muscle …

The genetics of bone mass and susceptibility to bone diseases

D Karasik, F Rivadeneira, ML Johnson - Nature Reviews Rheumatology, 2016 - nature.com
Osteoporosis is characterized by low bone mass and an increased risk of fracture. Genetic
factors, environmental factors and gene–environment interactions all contribute to a person's …

The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control

S Imai - NPJ systems biology and applications, 2016 - nature.com
The original concept of the NAD World was proposed in 2009, providing a comprehensive
framework to investigate critical issues of biological robustness and trade-offs in mammalian …

Similar sequences but dissimilar biological functions of GDF11 and myostatin

J Suh, YS Lee - Experimental & molecular medicine, 2020 - nature.com
Abstract Growth differentiation factor 11 (GDF11) and myostatin (MSTN) are closely related
TGFβ family members that are often believed to serve similar functions due to their high …

Antimyostatin treatment in health and disease: The story of great expectations and limited success

TL Nielsen, J Vissing, TO Krag - Cells, 2021 - mdpi.com
In the past 20 years, myostatin, a negative regulator of muscle mass, has attracted attention
as a potential therapeutic target in muscular dystrophies and other conditions. Preclinical …

Myostatin deficiency not only prevents muscle wasting but also improves survival in septic mice

M Kobayashi, S Kasamatsu… - American Journal …, 2021 - journals.physiology.org
Sepsis remains a leading cause of mortality in critically ill patients. Muscle wasting is a major
complication of sepsis and negatively affects clinical outcomes. Despite intense …

Genetics of bone and muscle interactions in humans

K Trajanoska, F Rivadeneira, DP Kiel… - Current osteoporosis …, 2019 - Springer
Abstract Purpose of Review To summarize the evidence from recent studies on the shared
genetics between bone and muscle in humans. Recent Findings Genome-wide association …

Widespread diversity in the transcriptomes of functionally divergent limb tendons

NP Disser, GC Ghahramani, JB Swanson… - The Journal of …, 2020 - Wiley Online Library
Key points Tendon is a hypocellular, matrix‐rich tissue that has been excluded from
comparative transcriptional atlases. These atlases have provided important knowledge …