Toward multi-targeted platinum and ruthenium drugs—a new paradigm in cancer drug treatment regimens?

RG Kenny, CJ Marmion - Chemical reviews, 2019 - ACS Publications
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

Half-sandwich ruthenium arene complexes bearing clinically approved drugs as ligands: The importance of metal–drug synergism in metallodrug design

C Sumithaa, M Ganeshpandian - Molecular pharmaceutics, 2023 - ACS Publications
A novel strategy in metallodrug discovery today is incorporating clinically approved drugs
into metal complexes as coordinating ligands. Using this strategy, various drugs have been …

8-Hydroxyquinolines in medicinal chemistry: A structural perspective

V Oliveri, G Vecchio - European journal of medicinal chemistry, 2016 - Elsevier
Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

WDJ Tremlett, DM Goodman, TR Steel, S Kumar… - Coordination chemistry …, 2021 - Elsevier
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

Impact of the halogen substitution pattern on the biological activity of organoruthenium 8-hydroxyquinoline anticancer agents

M Kubanik, H Holtkamp, T Sohnel… - …, 2015 - ACS Publications
8-Hydroxyquinoline and its derivatives have a broad variety of pharmacological properties,
which make them an ideal bioactive building block in the development of metal-based …

Quinoline-based metal complexes: Synthesis and applications

R Kumar, A Thakur, D Chandra, AK Dhiman… - Coordination Chemistry …, 2024 - Elsevier
Quinoline-based metal complexes have gained considerable attention in recent years due
to their applications in various fields, including catalysis, material sciences, and medicinal …

Synthesis and anticancer mechanisms of zinc (II)-8-hydroxyquinoline complexes with 1, 10-phenanthroline ancillary ligands

LQ Du, TY Zhang, XM Huang, Y Xu, MX Tan… - Dalton …, 2023 - pubs.rsc.org
Twenty new zinc (II) complexes with 8-hydroxyquinoline (H-Q1–H-Q6) in the presence of 1,
10-phenanthroline derivatives (D1–D10) were synthesized and formulated as [Zn (Q1) 2 …

High anticancer activity and apoptosis-and autophagy-inducing properties of novel lanthanide (III) complexes bearing 8-hydroxyquinoline-N-oxide and 1, 10 …

Y Yang, Z Zhou, ZZ Wei, QP Qin, L Yang… - Dalton Transactions, 2021 - pubs.rsc.org
In the quest for rare earth metal complexes with enhanced cancer chemotherapeutic
properties, the discovery of seven lanthanide (III) complexes bearing 8-hydroxyquinoline-N …

Structure-related mode-of-action differences of anticancer organoruthenium complexes with β-diketonates

S Seršen, J Kljun, K Kryeziu, R Panchuk… - Journal of medicinal …, 2015 - ACS Publications
A series of organoruthenium (II) chlorido complexes with fluorinated O, O-ligands [(η6-p-
cymene) Ru (F3C-acac-Ar) Cl](1a–6a) and their respective 1, 3, 5-triaza-7 …

Synthesis of two platinum (II) complexes with 2-methyl-8-quinolinol derivatives as ligands and study of their antitumor activities

QP Qin, SL Wang, MX Tan, YC Liu, T Meng… - European Journal of …, 2019 - Elsevier
Abstract Two platinum (II) complexes,[Pt (ClQ)(DMSO) Cl](ClQ-Pt) and [Pt (BrQ)(DMSO)
Cl](BrQ-Pt), with 5, 7-dichloro-2-methyl-8-quinolinol (H-ClQ) and 5, 7-dibromo-2-methyl-8 …