[HTML][HTML] Synthesis and biological evaluation of novel (thio) semicarbazone-based benzimidazoles as antiviral agents against human respiratory viruses
V Francesconi, E Cichero, S Schenone, L Naesens… - Molecules, 2020 - mdpi.com
Respiratory RNA viruses are responsible for recurrent acute respiratory illnesses that still
represent a major medical need. Previously we developed a large variety of benzimidazole …
represent a major medical need. Previously we developed a large variety of benzimidazole …
Exploration of thiourea-based scaffolds for the construction of bacterial ureases inhibitors
W Tabor, A Katsogiannou, D Karta… - ACS …, 2023 - ACS Publications
A series of 32 thiourea-based urease inhibitors were synthesized and evaluated against
native bacterial enzyme and whole cells of Sporosarcina pasteurii and Proteus mirabilis …
native bacterial enzyme and whole cells of Sporosarcina pasteurii and Proteus mirabilis …
Synthesis, Structures, and Solution Studies of a New Class of [Mo2O2S2]-Based Thiosemicarbazone Coordination Complexes
This paper deals with the synthesis, structural studies, and behavior in solution of
unprecedented coordination complexes built by the association of a panel of 14 …
unprecedented coordination complexes built by the association of a panel of 14 …
Triapine analogues and their copper (II) complexes: Synthesis, characterization, solution speciation, redox activity, cytotoxicity, and mR2 RNR inhibition
I Besleaga, I Stepanenko, TV Petrasheuskaya… - Inorganic …, 2021 - ACS Publications
Three new thiosemicarbazones (TSCs) HL 1–HL 3 as triapine analogues bearing a redox-
active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of HL 1–HL 3 …
active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of HL 1–HL 3 …
Inhibitory properties of aromatic thiosemicarbazones on mushroom tyrosinase: Synthesis, kinetic studies, molecular docking and effectiveness in melanogenesis …
K Hałdys, W Goldeman, M Jewgiński, E Wolińska… - Bioorganic …, 2018 - Elsevier
The group of 19 thiosemicarbazones (TSCs) were synthesized and its inhibitory activity
toward mushroom tyrosinase and ability to inhibition of melanogenesis in B16 cells were …
toward mushroom tyrosinase and ability to inhibition of melanogenesis in B16 cells were …
Design, synthesis and biological evaluation of novel thiosemicarbazones as cruzipain inhibitors
G Jasinski, E Salas-Sarduy, D Vega, L Fabian… - European Journal of …, 2023 - Elsevier
Based on the activity of 23 TSCs on CZ taken from the literature, we have developed a
QSAR model for predicting the activity of TSCs. New TSCs were designed and then tested …
QSAR model for predicting the activity of TSCs. New TSCs were designed and then tested …
Thiosemicarbazone derivatives: Evaluation as cruzipain inhibitors and molecular modeling study of complexes with cruzain
G Jasinski, E Salas-Sarduy, D Vega, L Fabian… - Bioorganic & Medicinal …, 2022 - Elsevier
The development of cruzipain inhibitors represents one of the most attractive challenges in
the search for drugs for the treatment of Chagas disease. A recombinant form of this enzyme …
the search for drugs for the treatment of Chagas disease. A recombinant form of this enzyme …
Cytotoxic and apoptotic effects of ternary silver (i) complexes bearing 2-formylpyridine thiosemicarbazones and 1, 10-phenanthroline
DES Silva, AB Becceneri, MC Solcia… - Dalton …, 2020 - pubs.rsc.org
New silver (I) compounds containing 2-formylpyridine-N (4)-R-thiosemicarbazones and 1,
10-phenanthroline (phen) were synthesized and characterized by spectroscopic techniques …
10-phenanthroline (phen) were synthesized and characterized by spectroscopic techniques …
From rational design to serendipity: discovery of novel thiosemicarbazones as potent trypanocidal compounds
Chagas disease is a major public health problem caused by Trypanosoma cruzi, with an
estimated 6–7 million people infected and 70 million at risk of infection. T. brucei gambiense …
estimated 6–7 million people infected and 70 million at risk of infection. T. brucei gambiense …
Structural, spectroscopic (IR, Raman, and NMR), quantum chemical, and molecular docking analysis of (E)-2-(2, 5-dimethoxybenzylidene) hydrazinecarbothioamide …
Thiosemicarbazides are an important class of compounds with pronounced biological
activities. In this contribution, the crystallographic structure of (E)-2-(2, 5 …
activities. In this contribution, the crystallographic structure of (E)-2-(2, 5 …