Respiratory RNA viruses are responsible for recurrent acute respiratory illnesses that still
represent a major medical need. Previously we developed a large variety of benzimidazole …

A series of 32 thiourea-based urease inhibitors were synthesized and evaluated against
native bacterial enzyme and whole cells of Sporosarcina pasteurii and Proteus mirabilis …

This paper deals with the synthesis, structural studies, and behavior in solution of
unprecedented coordination complexes built by the association of a panel of 14 …

Three new thiosemicarbazones (TSCs) HL 1–HL 3 as triapine analogues bearing a redox-
active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of HL 1–HL 3 …

The group of 19 thiosemicarbazones (TSCs) were synthesized and its inhibitory activity
toward mushroom tyrosinase and ability to inhibition of melanogenesis in B16 cells were …

Based on the activity of 23 TSCs on CZ taken from the literature, we have developed a
QSAR model for predicting the activity of TSCs. New TSCs were designed and then tested …

The development of cruzipain inhibitors represents one of the most attractive challenges in
the search for drugs for the treatment of Chagas disease. A recombinant form of this enzyme …

New silver (I) compounds containing 2-formylpyridine-N (4)-R-thiosemicarbazones and 1,
10-phenanthroline (phen) were synthesized and characterized by spectroscopic techniques …

Chagas disease is a major public health problem caused by Trypanosoma cruzi, with an
estimated 6–7 million people infected and 70 million at risk of infection. T. brucei gambiense …

Thiosemicarbazides are an important class of compounds with pronounced biological
activities. In this contribution, the crystallographic structure of (E)-2-(2, 5 …