Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …

Our understanding of G protein-coupled receptor (GPCR) activation has evolved during the
last ten years, both at a molecular level thanks to the resolution of several crystal structures …

In a departure from previous top-down or bottom-up strategies used to understand neuronal
circuits, many forward-looking research programs now place the circuit itself at their centre …

The unique perisynaptic distribution of postsynaptic metabotropic glutamate receptors
(mGluRs) at excitatory synapses is predicted to directly shape synaptic function, but …

Research on glutamatergic neurotransmission has focused mainly on the function of
presynaptic and postsynaptic neurons, leaving astrocytes with a secondary role only to …

Groundbreaking structural and spectroscopic studies of class AG protein-coupled receptors
(GPCRs), such as rhodopsin and the β 2 adrenergic receptor, have provided a picture of …

The eight metabotropic glutamate receptors (mGluRs) are key modulators of synaptic
transmission and are considered promising targets for the treatment of various brain …

Genetically encoded biosensors allow the noninvasive imaging of specific biochemical or
biorecognition processes with the preservation of subcellular spatial and temporal …