Reverse transcription and integration are the defining features of the Retroviridae; the
common name “retrovirus” derives from the fact that these viruses use a virally encoded …

Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …

Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins.
Substantial progress has been made toward understanding the function of each protein, and …

The human immunodeficiency virus (HIV) genome encodes a total of three structural
proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the …

It is almost 20 years since NNRTIs were identified as a new class of antiretroviral drugs for
the treatment of HIV-1 infection. Although they belong to different and diverse chemical …

Proteins are in constant motion between different conformational states with similar
energies. This has often been ignored in drug design. However, protein flexibility is …

The accurate simulation of DNA and RNA has been a goal of theoretical biophysicists for a
number of years. That is, given a high-resolution experimental structure, or perhaps a …

Numerous studies, both in enzymatic and nonenzymatic catalysis, have been undertaken to
understand the way by which metal ions, especially zinc ions, promote the hydrolysis of …

Anti-AIDS drug candidate and non-nucleoside reverse transcriptase inhibitor (NNRTI)
TMC125-R165335 (etravirine) caused an initial drop in viral load similar to that observed …

The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …