Proteins are structurally heterogeneous and comprise folded regions with variable
conformational stabilities and intrinsically disordered protein regions that do not have well …

The last five years have witnessed major developments in the understanding of the allosteric
phenomenon, broadly defined as coupling between remote molecular sites. Such advances …

Allostery is an essential regulatory mechanism of biological function. Allosteric sites are also
pharmacologically relevant as they are often targeted with higher selectivity than orthosteric …

Malaria is a life-threatening disease responsible for about a million fatalities per year
worldwide. Most of the malaria deaths are caused by Plasmodium falciparum. An essential …

In the nucleus, the spatiotemporal regulation of the catalytic subunit of cAMP-dependent
protein kinase A (PKA-C) is orchestrated by an intrinsically disordered protein kinase …

Protein Kinase A (PKA) is the major receptor for the cyclic adenosine monophosphate
(cAMP) secondary messenger in eukaryotes. cAMP binds to two tandem cAMP-binding …

The hyperpolarization-activated cyclic nucleotide-modulated (HCN) ion channels control
rhythmicity in neurons and cardiomyocytes. Cyclic AMP allosterically modulates HCN …

Elucidating the molecular mechanism of disease-related mutations (DRMs) is a critical first
step towards understanding the etiology of genetic disorders. DRMs often modulate …

The second messenger molecule cAMP regulates the activation phase of the cAMP
signaling pathway through high-affinity interactions with the cytosolic cAMP receptor, the …

The hyperpolarization‐activated cyclic‐nucleotide‐gated (HCN) ion channels control nerve
impulse transmission and cardiac pacemaker activity. The modulation by cAMP is critical for …