mRNA vaccines: The future of prevention of viral infections?

P Rzymski, A Szuster‐Ciesielska… - Journal of medical …, 2023 - Wiley Online Library
Messenger RNA (mRNA) vaccines against COVID‐19 are the first authorized biological
preparations developed using this platform. During the pandemic, their administration has …

Respiratory syncytial virus—a comprehensive review

AT Borchers, C Chang, ME Gershwin… - Clinical reviews in allergy …, 2013 - Springer
Respiratory syncytial virus (RSV) is amongst the most important pathogenic infections of
childhood and is associated with significant morbidity and mortality. Although there have …

Prefusion F protein–based respiratory syncytial virus immunization in pregnancy

EAF Simões, KJ Center, ATN Tita… - … England Journal of …, 2022 - Mass Medical Soc
Background Respiratory syncytial virus (RSV), a major cause of illness and death in infants
worldwide, could be prevented by vaccination during pregnancy. The efficacy …

Development of mRNA vaccines against respiratory syncytial virus (RSV)

X Qiu, S Xu, Y Lu, Z Luo, Y Yan, C Wang, J Ji - Cytokine & Growth Factor …, 2022 - Elsevier
Respiratory syncytial virus (RSV) is a single-stranded negative-sense RNA virus that is the
primary etiologic pathogen of bronchitis and pneumonia in infants and the elderly. Currently …

Mortality associated with influenza and respiratory syncytial virus in the United States

WW Thompson, DK Shay, E Weintraub, L Brammer… - Jama, 2003 - jamanetwork.com
Context Influenza and respiratory syncytial virus (RSV) cause substantial morbidity and
mortality. Statistical methods used to estimate deaths in the United States attributable to …

Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years

PL Collins, JA Melero - Virus research, 2011 - Elsevier
Human respiratory syncytial virus (RSV) is a ubiquitous pathogen that infects everyone
worldwide early in life and is a leading cause of severe lower respiratory tract disease in the …

B-cell responses to vaccination at the extremes of age

CA Siegrist, R Aspinall - Nature Reviews Immunology, 2009 - nature.com
Infants and the elderly share a high vulnerability to infections and therefore have specific
immunization requirements. Inducing potent and sustained B-cell responses is as …

[HTML][HTML] Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children

JV Williams, PA Harris, SJ Tollefson… - … England Journal of …, 2004 - Mass Medical Soc
Background We sought to determine the role of human metapneumovirus in lower
respiratory tract illness in previously healthy infants and children. Methods We tested nasal …

Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

C Cruz-Teran, K Tiruthani, M McSweeney, A Ma… - Advanced drug delivery …, 2021 - Elsevier
To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …

Suppression of the induction of alpha, beta, and gamma interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and …

KM Spann, KC Tran, B Chi, RL Rabin… - Journal of virology, 2004 - Am Soc Microbiol
Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta
interferons (IFN-α/β). However, recombinant HRSV lacking the NS1 and NS2 genes …