As early as the 1920s, and subsequently in the 1959 Build and Blood Pressure Study (S1. 5-
1) of almost 5 million adults insured between 1934 and 1954, a strong direct relationship …

Executive summary Rapid demographic, sociocultural, and economic transitions are driving
increases in the risk and prevalence of diabetes and other non-communicable diseases …

Background: The 2017 American College of Cardiology/American Heart Association
(ACC/AHA) Guideline for the Prevention, Detection, Evaluation and Management of High …

Importance The appropriate treatment target for systolic blood pressure (SBP) in older
patients with hypertension remains uncertain. Objective To evaluate the effects of intensive …

• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Despite the vast amount of evidence on the benefits of blood pressure lowering
accumulated to date, elevated blood pressure is still the leading risk factor for disease and …

Background On the basis of the 2014 guidelines for hypertension therapy in the United
States, many eligible adults remain untreated. We projected the cost-effectiveness of treating …

The Million Hearts Initiative has a goal of preventing 1 million heart attacks and strokes—the
leading causes of mortality—through several public health and healthcare strategies by …

Importance Older patients with diabetes mellitus receiving medical treatment whose blood
pressure (BP) or blood glucose level are potentially dangerously low are rarely …

Importance Large improvements in the control of risk factors for cardiovascular disease have
been achieved in the United States, but it remains unclear whether adults in all …